A unipolar intersub-band semiconductor laser operating above liquid nitrogen temperature at 4.3mum wavelength is reported. The measured optical power in pulsed operation is 30mW at 102K and the slope efficiency 0.1W/A. Strong line-narrowing above threshold and well resolved longitudinal modes are observed up to 125K. This new light source, called the quantum cascade laser, is based on sequential photon emission in a staircase/coupled quantum well AlInAs/GaInAs structure grown by MBE and its wavelength can be tailored in an extremely wide region.