AGE-RELATED ALTERATIONS IN 2ND MESSENGER SYSTEMS IN THE GERBIL BRAIN - AUTORADIOGRAPHIC ANALYSIS AND EFFECT OF VINCONATE

被引:3
作者
ARAKI, T [1 ]
KANAI, Y [1 ]
KATO, H [1 ]
KOGURE, K [1 ]
ISHIDA, Y [1 ]
机构
[1] TOKYO TANABE,RES LABS,PHARMACOL RES LAB,TOKYO 115,JAPAN
关键词
AGING; 2ND MESSENGERS; RECEPTOR; VINCONATE; GERBIL;
D O I
10.1007/BF02576278
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Age-related alterations in binding sites of major second-messenger systems in the gerbil brain were analyzed by receptor autoradiography using [H-3]phorbol 12, 13-dibutyrate (PDBu), and [H-3]inositol 1,4,5-trisphosphate (IP3). In middle-aged gerbils (16 months old), the reduction of PDBu-binding sites was noticed in various brain regions compared with young animals (4 weeks old). By contrast, the elevation Of IP3-binding sites was seen in most of brain regions except for the reduction in the cerebellum in the middle-aged animals. Chronic treatment with vinconate partly regulated the age-related changes in the binding sites of these second messengers. The result demonstrates the age-related alterations in the binding sites of an intracellular second-messenger system. Furthermore, they suggest that vinconate partly modulates the age-related alterations in the bindings of second messengers.
引用
收藏
页码:221 / 230
页数:10
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