DIRECT ENANTIOSELECTIVE SEPARATION OF BEVANTOLOL BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON NORMAL AND REVERSE CELLULOSE CHIRAL STATIONARY PHASES

被引：27

作者：

ABOULENEIN, HY

SERIGNESE, V

机构：

[1] Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211

来源：

BIOMEDICAL CHROMATOGRAPHY | 1994年 / 8卷 / 01期

关键词：

D O I：

10.1002/bmc.1130080106

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A direct, isocratic and simple chromatographic method is described for the enantiomeric separation Of bevantolol (BEV) using normal and reverse cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phases (CSPs) known as Chiralcel OD and Chiralcel OD-R, respectively. The effect of various alcohols present in the mobile phase on the separation factor (alpha) and resolution factor (R(s)) has been studied. The method has been used to determine and identify the BEV enantiomers in human urine after oral administration of racemic BEV. The chiral recognition mechanism(s) between the analyte and these chiral stationary phases is proposed.

引用

页码：22 / 25

页数：4

共 23 条

[1] APPLICATIONS OF CELLULOSE-BASED CHIRAL STATIONARY PHASES IN THE RESOLUTION OF SOME BETA-ADRENOCEPTOR ANTAGONISTS [J].

ABOULENEIN, HY .

ANALYTICAL LETTERS, 1993, 26 (02) :271-279

[2] DIRECT HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF PENBUTOLOL ENANTIOMERS ON A CELLULOSE TRIS-3,5-DIMETHYLPHENYL CARBAMATE CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

ISLAM, MR .

CHIRALITY, 1989, 1 (04) :301-304

[3]

ABOULENEIN HY, 1990, ANAL LETT, V23, P973

[4] DIRECT SEPARATION AND OPTIMIZATION OF TIMOLOL ENANTIOMERS ON A CELLULOSE TRIS-3,5-DIMETHYLPHENYLCARBAMATE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

ISLAM, MR .

JOURNAL OF CHROMATOGRAPHY, 1990, 511 :109-114

[5] DIRECT HPLC SEPARATION AND OPTIMIZATION OF CELIPROLOL ENANTIOMERS [J].

ABOULENEIN, HY ;

ISLAM, MR .

ANALYTICAL LETTERS, 1990, 23 (01) :83-91

[6] ROLE OF SOLVENTS IN THE RESOLUTION OF SOME BETA-ADRENERGIC BLOCKERS ON CELLULOSE 3,5-DIMETHYLPHENYL CARBAMATE CHIRAL STATIONARY PHASE [J].

ABOULENEIN, HY ;

SERIGNESE, V .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1993, 16 (01) :197-207

[7]

BARRETT AM, 1968, BRIT J PHARMACOL, V13, P43

[8] ABSOLUTE CONFIGURATION BY ASYMMETRIC SYNTHESIS OF (+)-1-(4-ACETAMIDOPHENOXY)-3-(ISOPROPYLAMINO)-PROPAN-2-OL (PRACTOLOL) [J].

DANILEWICZ, JC ;

KEMP, JEG .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (02) :168-169

[9] BEVANTOLOL - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC EFFICACY IN HYPERTENSION AND ANGINA-PECTORIS [J].

FRISHMAN, WH ;

GOLDBERG, RJ ;

BENFIELD, P .

DRUGS, 1988, 35 (01) :1-21

[10] DIRECT SEPARATION OF ENANTIOMERS BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON CELLULOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE) [J].

IKEDA, K ;

HAMASAKI, T ;

KOHNO, H ;

OGAWA, T ;

MATSUMOTO, T ;

SAKAI, JI .

CHEMISTRY LETTERS, 1989, (06) :1089-1090

← 1 2 3 →