THE REGULATION OF KIDNEY DEVELOPMENT - NEW INSIGHTS FROM AN OLD MODEL

被引:32
作者
PATTERSON, LT
DRESSLER, GR
机构
[1] Department of Health, Human Services, National Institute of Child Health and Human Development, Bethesda
关键词
D O I
10.1016/0959-437X(94)90136-Q
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The embryonic kidney is an excellent model system in which to address many fundamental issues in developmental biology. Inductive interactions are required for proliferation and differentiation of the ureter epithelium and kidney mesenchyme. Recent studies implicate a receptor-type tyrosine kinase as a target of inductive signals in the developing ureter. In the mesenchyme, the early induction response requires at least two transcription factors, WT1 and Pax-2. Through the integrated application of in vitro culture models and gene targeting methods, the molecular mechanisms underlying kidney morphogenesis are becoming clearer.
引用
收藏
页码:696 / 702
页数:7
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