A NOVEL PEPTIDE ISOLATED FROM THE LEAVES OF GYMNEMA-SYLVESTRE .1. CHARACTERIZATION AND ITS SUPPRESSIVE EFFECT ON THE NEURAL RESPONSES TO SWEET TASTE STIMULI IN THE RAT

被引：88

作者：

IMOTO, T ^{[1
]}

MIYASAKA, A ^{[1
]}

ISHIMA, R ^{[1
]}

AKASAKA, K ^{[1
]}

机构：

[1] KYOTO UNIV,FAC SCI,DEPT CHEM,KYOTO 606,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1991年 / 100卷 / 02期

关键词：

D O I：

10.1016/0300-9629(91)90475-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. A new substance that suppressed selectively the neural responses of the rat to sweet taste stimuli was isolated from the leaves of Gymnema sylvestre. 2. The substance was proved to be a peptide consisting of 35 amino acids and having a molecular weight of about 4,000. 3. The inhibitory effect on the sweet responses appeared after treating the tongue surface with the peptide at a concentration of more than 1 x 10(-6) M.

引用

页码：309 / 314

页数：6

共 18 条

[1]

EDGEWORTH P, 1847, P LINN SOC LONDON, V7, P351

[2] SWEET TASTE INVOLVES SEVERAL DISTINCT RECEPTOR MECHANISMS [J].