ONLINE AND IN-SITU MONITORING TECHNOLOGY FOR CELL-DENSITY MEASUREMENT IN MICROBIAL AND ANIMAL-CELL CULTURES

被引:21
作者
JUNKER, BH
REDDY, J
GBEWONYO, K
GREASHAM, R
机构
来源
BIOPROCESS ENGINEERING | 1994年 / 10卷 / 5-6期
关键词
D O I
10.1007/s004490050044
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Commercially available on-line and in-situ devices for monitoring cell density are reviewed in this article. Principles of operation are described as well as capabilities of these probes in specific measurement applications based on literature reports. Pilot-scale experimental observations from three optical density probes, the Cerex, Monitek and Wedgewood designs, have been included for Escherichia coli fermentations. Requirements for future on-line and in-situ instruments are discussed as well as the impact of current imitations on widespread application.
引用
收藏
页码:195 / 207
页数:13
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