HYDROXY-DIRECTED KETONE REDUCTION - APPLICATION TO THE SYNTHESIS OF (+)-8,8A-DIEPICASTANOSPERMINE

被引：16

作者：

THOMPSON, SHJ

SUBRAMANIAN, RS

ROBERTS, JK

HADLEY, MS

GALLAGHER, T

机构：

[1] UNIV BRISTOL,SCH CHEM,BRISTOL BS8 1TS,AVON,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 08期

关键词：

D O I：

10.1039/c39940000933

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reduction of heterocyclic-derived aldol adducts 2 and 3 using NaBH(OAc)(3) is stereoselective and proceeds via a hydroxy-directed mechanism to give 6 and 7, respectively, thereby complementing the stereoselectivity available with NaBH4; a synthesis of (+)-8,8a-diepicastanospermine 11 from diol 6 is described.

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页码：933 / 934

页数：2

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