NEUROENDOCRINE PEPTIDES IN THE PROSTATE

被引:77
作者
GKONOS, PJ
KRONGRAD, A
ROOS, BA
机构
[1] UNIV MIAMI,SCH MED,DEPT MED,MIAMI,FL 33101
[2] UNIV MIAMI,SCH MED,SYLVESTER COMPREHENS CANC CTR,MIAMI,FL 33101
[3] UNIV MIAMI,SCH MED,DEPT UROL,MIAMI,FL 33101
[4] UNIV MIAMI,SCH MED,DEPT NEUROL,MIAMI,FL 33101
来源
UROLOGICAL RESEARCH | 1995年 / 23卷 / 02期
关键词
PROSTATE; PROSTATE CARCINOMA; NEUROPEPTIDES; NEUROENDOCRINE CELLS;
D O I
10.1007/BF00307937
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Circulating androgens are required for normal growth and maintenance of function of the prostate. However, the prostate also contains neuroendocrine peptides, found either in nerve terminals or in prostatic neuroendocrine cells, which are likely to regulate prostate growth or function. The neuronal peptides are likely to participate in the regulation of the synthesis and secretion of prostatic secretory products. While the function of the neuroendocrine cells is undefined, there is evidence for growth-regulating effects of several neuroendocrine cell peptides. Since neuroendocrine differentiation has been correlated with tumor grade and poor prognosis in prostate cancer, the peptide products of the neuroendocrine cells may influence cancer cell replication as well. Recent evidence in other tissues suggests that peptide hormone receptor second-messenger systems may interact with steroid receptors to modulate their actions. These findings raise the possibility that prostatic neuroendocrine peptides may modulate the response of prostate to androgens.
引用
收藏
页码:81 / 87
页数:7
相关论文
共 72 条
[11]   PARATHYROID-HORMONE RELATED PEPTIDE CAN FUNCTION AS AN AUTOCRINE GROWTH-FACTOR IN HUMAN RENAL-CELL CARCINOMA [J].
BURTON, PBJ ;
MONIZ, C ;
KNIGHT, DE .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (03) :1134-1138
[12]   VIP BINDING TO EPITHELIAL-CELL MEMBRANES OF RAT VENTRAL PROSTATE - EFFECT OF GUANINE-NUCLEOTIDES [J].
CARMENA, MJ ;
PRIETO, JC .
GENERAL PHARMACOLOGY, 1985, 16 (05) :495-500
[13]   CYCLIC-AMP RESPONSE TO VASOACTIVE-INTESTINAL-PEPTIDE AND BETA-ADRENERGIC OR CHOLINERGIC AGONISTS IN ISOLATED EPITHELIAL-CELLS OF RAT VENTRAL PROSTATE [J].
CARMENA, MJ ;
PRIETO, JC .
BIOSCIENCE REPORTS, 1985, 5 (09) :791-797
[14]   THE INNERVATION OF THE HUMAN PROSTATE-GLAND - THE CHANGES ASSOCIATED WITH BENIGN ENLARGEMENT [J].
CHAPPLE, CR ;
CROWE, R ;
GILPIN, SA ;
GOSLING, J ;
BURNSTOCK, G .
JOURNAL OF UROLOGY, 1991, 146 (06) :1637-1644
[15]   RELATIONSHIP OF NEUROENDOCRINE CELLS OF PROSTATE AND SEROTONIN TO BENIGN PROSTATIC HYPERPLASIA [J].
COCKETT, ATK ;
DISANTAGNESE, PA ;
GOPINATH, P ;
SCHOEN, SR ;
ABRAHAMSSON, PA .
UROLOGY, 1993, 42 (05) :512-519
[16]   THE TRH-RELATED PEPTIDE PYROGLUTAMYLGLUTAMYLPROLINAMIDE IS PRESENT IN HUMAN-SEMEN [J].
COCKLE, SM ;
AITKEN, A ;
BEG, F ;
MORRELL, JM ;
SMYTH, DG .
FEBS LETTERS, 1989, 252 (1-2) :113-117
[17]  
COCKLE SM, 1989, J BIOL CHEM, V264, P7788
[18]   NEUROENDOCRINE CELLS - A NEW PROGNOSTIC PARAMETER IN PROSTATE-CANCER [J].
COHEN, RJ ;
GLEZERSON, G ;
HAFFEJEE, Z .
BRITISH JOURNAL OF UROLOGY, 1991, 68 (03) :258-262
[19]   PROSTATIC-CARCINOMA - HISTOLOGICAL AND IMMUNOHISTOLOGICAL FACTORS AFFECTING PROGNOSIS [J].
COHEN, RJ ;
GLEZERSON, G ;
HAFFEJEE, Z ;
AFRIKA, D .
BRITISH JOURNAL OF UROLOGY, 1990, 66 (04) :405-410
[20]   THE NEUROENDOCRINE CELL-POPULATION OF THE HUMAN PROSTATE-GLAND [J].
COHEN, RJ ;
GLEZERSON, G ;
TAYLOR, LF ;
GRUNDLE, HAJ ;
NAUDE, JH .
JOURNAL OF UROLOGY, 1993, 150 (02) :365-368