IRREVERSIBLE ENZYME INHIBITORS .69. CANDIDATE ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE .3. BROMOACYL DERIVATIVES OF 5-(P-AMINOPHENOXYPROPYL)-2,4,6-TRIAMINOPYRIMIDINES

被引：6

作者：

BAKER, BR

SANTI, DV

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1967年 / 56卷 / 03期

关键词：

D O I：

10.1002/jps.2600560315

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：380 / &

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[11] IRREVERSIBLE ENZYME INHIBITORS .68. 2-AMINO-5-(P-BROMOACETAMIDOPHENOXYPROPYL)-6-PHENYL-4-PYRIMIDINOL AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE
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[14] ANALOGS OF TETRAHYDROFOLOC ACID 34 - HYDROPHOBIC BONDING TO DIHYDROFOLOC REDUCTASE .6. MODE OF PHENYL BINDING OF SOME 6-ARYLPYRIMIDINES
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[15] ANALOGS OF TETRAHYDROFOLIC ACID .35. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .7. SPECIES DIFFERENCES WITH SUBSTITUTED 4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES
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[16] ANALOGS OF TETRAHYDROFOLIC ACID .31. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .3. FURTHER OBSERVATIONS ON CONFORMATIONAL ASPECTS OF HYDROPHOBIC BONDING WITH SOME 5-ALKYL-2,4-DIAMINO-6-PYRIMIDINOLS
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[17] NONCLASSICAL ANTIMETABOLITES .15. BRIDGE PRINCIPLE OF SPECIFICITY WITH ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS .6. HIGHLY SELECTIVE IRREVERSIBLE INHIBITION OF LACTIC DEHYDROGENASE
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[18] ANALOGS OF TETRAHYDROFOLIC ACID .21. SYNTHESIS OF 6-BROMOMETHYL-5-(P-CHLOROPHENYL)-2,4-DIAMINOPYRIMIDINE AND ITS EVALUATION AS A DIHYDROFOLIC REDUCTASE INHIBITOR
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[19] ANALOGS OF TETRAHYDROFOLIC ACID .24. FACILE SYNTHETIC ROUTE TO 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE + THYMIDYLATE SYNTHETASE INHIBITOR
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[20] ANALOGS OF TETRAHYDROFOLIC ACID 28 - MODE OF PYRIMIDINE BINDING TO DIHYDROFOLIC REDUCTASE PH PROFILE STUDIES
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