内皮细胞型一氧化氮合酶基因多态性与血管性疾病的关系

被引:15
作者
朴翔宇
陶定波
机构
[1] 大连医科大学附属第四临床医院神经内科
[2] 大连医科大学附属第一临床医院神经内科
关键词
一氧化氮合酶; 基因多态性; 动脉粥样硬化;
D O I
暂无
中图分类号
R543.5 [动脉疾病];
学科分类号
100201 [内科学];
摘要
内皮细胞型一氧化氮合酶基因是动脉粥样硬化性血管病的易感基因,该基因的多态性与颈动脉粥样硬化斑块、缺血性卒中、心血管病、高血压病以及糖尿病肾病等血管性疾病的发生和发展有一定的相关性。
引用
收藏
页码:305 / 307
页数:3
相关论文
共 11 条
[1]
Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients [J].
Hou, L ;
Osei-Hyiaman, D ;
Yu, H ;
Ren, Z ;
Zhang, Z ;
Wang, B ;
Harada, S .
NEUROLOGY, 2001, 56 (04) :490-496
[2]
No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke [J].
Akar, N ;
Akar, E ;
Deda, G ;
Sipahi, T .
NEUROLOGY, 2000, 55 (03) :460-461
[3]
Positive association of endothelial nitric oxide synthase gene polymorphism with hypertension in northern Japan [J].
Shoji, M ;
Tsutaya, S ;
Saito, R ;
Takamatu, H ;
Yasujima, M .
LIFE SCIENCES, 2000, 66 (26) :2557-2562
[4]
Lack of association between 27-bp repeat polymorphism in intron 4 of the endothelial nitric oxide synthase gene and the risk of coronary artery disease [J].
Sigusch, HH ;
Surber, R ;
Lehmann, MH ;
Surber, S ;
Weber, J ;
Henke, A ;
Reinhardt, D ;
Hoffmann, A ;
Figulla, HR .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2000, 60 (03) :229-235
[5]
Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy [J].
Fujita, H ;
Narita, T ;
Meguro, H ;
Ishii, T ;
Hanyu, O ;
Suzuki, K ;
Kamoi, K ;
Ito, S .
HORMONE AND METABOLIC RESEARCH, 2000, 32 (02) :80-83
[6]
No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke [J].
MacLeod, MJ ;
Dahiyat, MT ;
Cumming, A ;
Meiklejohn, D ;
Shaw, D ;
St Clair, D .
NEUROLOGY, 1999, 53 (02) :418-420
[7]
Nitric oxide synthase gene polymorphism and its influence on cardiovascular disease [J].
Soma, M ;
Nakayama, T ;
Kanmatsuse, K .
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1999, 8 (01) :83-87
[8]
The 27-bp repeat polymorphism in intron 4 of the endothelial cell nitric oxide synthase gene and ischemic stroke in a Japanese population [J].
Yahashi, Y ;
Kario, K ;
Shimada, K ;
Matsuo, M .
BLOOD COAGULATION & FIBRINOLYSIS, 1998, 9 (05) :405-409
[9]
Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans [J].
Tsukada, T ;
Yokoyama, K ;
Arai, T ;
Takemoto, F ;
Hara, S ;
Yamada, A ;
Kawaguchi, Y ;
Hosoya, T ;
Igari, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (01) :190-193
[10]
Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population [J].
Ichihara, S ;
Yamada, Y ;
Fujimura, T ;
Nakashima, N ;
Yokota, M .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (01) :83-+