Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance

被引：16

作者：

Panda, Shikshya S. ^{[1
]}

Sahoo, Rajeev K. ^{[1
]}

Patra, Sambit K. ^{[1
]}

Biswal, Stuti ^{[1
]}

Biswal, Bijesh K. ^{[1
]}

机构：

[1] Natl Inst Technol Rourkela, Dept Life Sci, Canc Drug Resistance Lab, Rourkela 769008, Odisha, India

来源：

DRUG DISCOVERY TODAY | 2024年 / 29卷 / 08期

关键词：

Cancer; exosome; tumor microenvironment; tumor heterogeneity; metastasis; drug resistance; BREAST-CANCER; MACROPHAGES; SUPPRESSION; DELIVERY; CELLS;

D O I：

10.1016/j.drudis.2024.104061

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Exosomes play a pivotal part in cancer progression and metastasis by transferring various biomolecules. Recent research highlights their involvement in tumor microenvironment remodeling, mediating metastasis, tumor heterogeneity and drug resistance. The unique cargo carried by exosomes garners the interest of researchers owing to its potential as a stage-specific biomarker for early cancer detection and its role in monitoring personalized treatment. However, unanswered questions hinder a comprehensive understanding of exosomes and their cargo in this context. This review discusses recent advancements and proposes novel ideas for exploring exosomes in cancer progression, aiming to deepen our understanding and improve treatment approaches.

引用

收藏

页数：15

相关论文

共 138 条

[1]

Exosomes: Emerging modulators of signal transduction in colorectal cancer from molecular understanding to clinical application [J].

Bahrami, Afsane ;

Binabaj, Maryam Moradi ;

Ferns, Gordon A. .

BIOMEDICINE & PHARMACOTHERAPY, 2021, 141

[2]

Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis [J].

Bai, Suwen ;

Wang, Zunyun ;

Wang, Minghua ;

Li, Junai ;

Wei, Yuan ;

Xu, Ruihuan ;

Du, Juan .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10

[3]

Role of tumour-derived exosomes in metastasis [J].

Bai, Suwen ;

Wei, Yuan ;

Liu, Rong ;

Xu, Ruihuan ;

Xiang, Li ;

Du, Juan .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 147

[4]

Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma [J].

Bai, Xiaoming ;

Shao, Jiaofang ;

Duan, Tinghong ;

Liu, Xue ;

Wang, Min ;

Li, Xuanya ;

You, Qiang ;

Zhang, Zhiyuan ;

Pan, Jinshun .

CELL COMMUNICATION AND SIGNALING, 2023, 21 (01)

[5]

Exosomal miR-93 derived from hepatocellular carcinoma cell promotes the sorafenib resistance of hepatocellular carcinoma through PTEN/PI3K/Akt pathway [J].

Bao, Yuanpeng ;

Xu, Song ;

Zhou, Junjing ;

Zhao, Chongyong ;

Dai, Saimin ;

Zhang, Yong ;

Rao, Min .

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2024, 38 (03)

[6]

Role of Exosomes in Epithelial-Mesenchymal Transition [J].

Bhattacharya, Bikramjit ;

Nag, Sagnik ;

Mukherjee, Sayantanee ;

Kulkarni, Mrunal ;

Chandane, Priti ;

Mandal, Debashmita ;

Mukerjee, Nobendu ;

Mirgh, Divya ;

Anand, Krishnan ;

Adhikari, Manab Deb ;

Gorai, Sukhamoy ;

Thorat, Nanasaheb .

ACS APPLIED BIO MATERIALS, 2023, 7 (01) :44-58

[7]

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches [J].

Bin Emran, Talha ;

Shahriar, Asif ;

Mahmud, Aar Rafi ;

Rahman, Tanjilur ;

Abir, Mehedy Hasan ;

Siddiquee, Mohd. Faijanur-Rob ;

Ahmed, Hossain ;

Rahman, Nova ;

Nainu, Firzan ;

Wahyudin, Elly ;

Mitra, Saikat ;

Dhama, Kuldeep ;

Habiballah, Mahmoud M. ;

Haque, Shafiul ;

Islam, Ariful ;

Hassan, Mohammad Mahmudul .

FRONTIERS IN ONCOLOGY, 2022, 12

[8]

Tumour microenvironment and aberrant signaling pathways in cisplatin resistance and strategies to overcome in oral cancer [J].

Biswal, Stuti ;

Panda, Munmun ;

Sahoo, Rajeev K. ;

Tripathi, Surya Kant ;

Biswal, Bijesh K. .

ARCHIVES OF ORAL BIOLOGY, 2023, 151

[9]

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells [J].

Chen, Fei ;

Chen, Jianing ;

Yang, Linbin ;

Liu, Jiang ;

Zhang, Xiaoqian ;

Zhang, Yin ;

Tu, Qingqiang ;

Yin, Dong ;

Lin, Dechen ;

Wong, Ping-Pui ;

Huang, Di ;

Xing, Yue ;

Zhao, Jinghua ;

Li, Mengfeng ;

Liu, Qiang ;

Su, Fengxi ;

Su, Shicheng ;

Song, Erwei .

NATURE CELL BIOLOGY, 2019, 21 (04) :498-+

[10]

Intimate communications within the tumor microenvironment: stromal factors function as an orchestra [J].

Cheng, Bing ;

Yu, Qiang ;

Wang, Wenyu .

JOURNAL OF BIOMEDICAL SCIENCE, 2023, 30 (01)

← 1 2 3 4 5 6 7 8 9 10 →