Tunable c-MYC LNA i-motif

被引：18

作者：

Kumar, Niti ^{[1
]}

Petersen, Michael ^{[2
]}

Maiti, Souvik ^{[1
]}

机构：

[1] CSIR, Struct Biol Unit, Inst Genom & Integrat Biol, Delhi 110007, India

[2] Univ So Denmark, Nucle Acid Ctr, Dept Chem & Phys, DK-5230 Odense M, Denmark

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 12期

关键词：

DRIVEN CONFORMATIONAL SWITCH; COMPLEMENTARY STRAND; TETRAPLEX FORMATION; SMALL-MOLECULE; G-QUADRUPLEX; RICH STRAND; DNA; PROMOTER; THERMODYNAMICS; BINDING;

D O I：

10.1039/b819305c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using spectroscopic techniques, we demonstrate the effect of LNA (locked nucleic acid) nucleotides in modulating the formation and stability of the i-motif structure formed by the c-MYC sequence.

引用

页码：1532 / 1534

页数：3

共 45 条

[1] HUMAN TELOMERIC C-STRAND TETRAPLEXES [J].

AHMED, S ;

KINTANAR, A ;

HENDERSON, E .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (02) :83-88

[2] Stabilization of the DNA I-motif structure by incorporation of 3′-S-phosphorothiolate linkages [J].

Brazier, JA ;

Fisher, J ;

Cosstick, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (01) :114-117

[3] Molecular modeling and biophysical analysis of the c-MYC NHE-III1 silencer element [J].

Cashman, Derek J. ;

Buscaglia, Robert ;

Freyer, Matthew W. ;

Dettler, Jamie ;

Hurley, Laurence H. ;

Lewis, Edwin A. .

JOURNAL OF MOLECULAR MODELING, 2008, 14 (02) :93-101

[4] The RNA2-PNA2 hybrid i-motif -: a novel RNA-based building block [J].

Chakraborty, Saikat ;

Modi, Souvik ;

Krishnan, Yamuna .

CHEMICAL COMMUNICATIONS, 2008, (01) :70-72

[5] DDP1, a single-stranded nucleic acid-binding protein of Drosophila, associates with pericentric heterochromatin and is functionally homologous to the yeast Scp160p, which is involved in the control of cell ploidy [J].

Cortés, A ;

Huertas, D ;

Fanti, L ;

Pimpinelli, S ;

Marsellach, FX ;

Piña, B ;

Azorín, F .

EMBO JOURNAL, 1999, 18 (13) :3820-3833

[6] i-motif solution structure and dynamics of the d(AACCCC) and d(CCCCAA) tetrahymena telomeric repeats [J].

Esmaili, N ;

Leroy, JL .

NUCLEIC ACIDS RESEARCH, 2005, 33 (01) :213-224

[7] The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability [J].

Fenna, Clare P. ;

Wilkinson, Victoria J. ;

Arnold, John R. P. ;

Cosstick, Richard ;

Fisher, Julie .

CHEMICAL COMMUNICATIONS, 2008, (30) :3567-3569

[8] Controlling DNA polymerization with a switchable aptamer [J].

Friedrichs, Eike ;

Simmel, Friedrich C. .

CHEMBIOCHEM, 2007, 8 (14) :1662-1666

[9] A TETRAMERIC DNA-STRUCTURE WITH PROTONATED CYTOSINE.CYTOSINE BASE-PAIRS [J].

GEHRING, K ;

LEROY, JL ;

GUERON, M .

NATURE, 1993, 363 (6429) :561-565

[10]

GHODKE HB, 2006, ANGEW CHEM INT EDIT, V45, P114

← 1 2 3 4 5 →