Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity

被引：446

作者：

Zhang, Guojie ^{[1
,2
]}

Cowled, Christopher ^{[3
]}

Shi, Zhengli ^{[4
]}

Huang, Zhiyong ^{[1
]}

Bishop-Lilly, Kimberly A. ^{[5
,6
]}

Fang, Xiaodong ^{[1
]}

Wynne, James W. ^{[3
]}

Xiong, Zhiqiang ^{[1
]}

Baker, Michelle L. ^{[3
]}

Zhao, Wei ^{[1
]}

Tachedjian, Mary ^{[3
]}

Zhu, Yabing ^{[1
]}

Zhou, Peng ^{[3
,4
]}

Jiang, Xuanting ^{[1
]}

Ng, Justin ^{[3
]}

Yang, Lan ^{[1
]}

Wu, Lijun ^{[4
]}

Xiao, Jin ^{[1
]}

Feng, Yue ^{[1
]}

Chen, Yuanxin ^{[1
]}

Sun, Xiaoqing ^{[1
]}

Zhang, Yong ^{[1
]}

Marsh, Glenn A. ^{[3
]}

Crameri, Gary ^{[3
]}

Broder, Christopher C. ^{[7
]}

Frey, Kenneth G. ^{[5
,6
]}

Wang, Lin-Fa ^{[3
,8
]}

Wang, Jun ^{[1
,9
,10
]}

机构：

[1] BGI Shenzhen, Shenzhen 518083, Peoples R China

[2] Univ Copenhagen, Dept Biol, Ctr Social Evolut, DK-2100 Copenhagen, Denmark

[3] CSIRO, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia

[4] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China

[5] USN, Med Res Ctr, Frederick, MD 21702 USA

[6] Henry M Jackson Fdn, Frederick, MD 21702 USA

[7] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA

[8] Duke Natl Univ Singapore Grad Med Sch, Program Emerging Infect Dis, Singapore 169857, Singapore

[9] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark

[10] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

来源：

SCIENCE | 2013年 / 339卷 / 6118期

基金：

中国国家自然科学基金; 澳大利亚研究理事会;

关键词：

PHYLOGENY; ACTIVATION; PATHWAYS; PROTEIN; FAMILY; P53;

D O I：

10.1126/science.1230835

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor kappa B pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.

引用

页码：456 / 460

页数：5

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