天然镇痛活性成分研究进展

被引：7

作者：

匡岩巍

张庆林

机构：

[1] 军事医学科学院放射与辐射医学研究所

来源：

国外医学药学分册. | 2006年 / 05期

关键词：

天然产物; 镇痛; 活性成分;

D O I：

10.13220/j.cnki.jipr.2006.05.009

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

天然镇痛活性成分一直是药物研发的热点之一。随着对海洋生物、微生物研究的深入和扩展,发现了许多结构新颖,活性独特的新型天然镇痛活性成分。本文综合了国外文献报道,按结构类型对新发现的天然镇痛活性成分进行分类,综述其研究现状。

引用

页码：344 / 347

页数：4

共 10 条

[1]

Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa [J].

Matsumoto, K ;

Horie, S ;

Takayama, H ;

Ishikawa, H ;

Aimi, N ;

Ponglux, D ;

Murayama, T ;

Watanabe, K .

LIFE SCIENCES, 2005, 78 (01) :2-7

[2]

The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs [J].

Barton, ME ;

White, HS ;

Wilcox, KS .

EPILEPSY RESEARCH, 2004, 59 (01) :13-24

[3]

8-O-cinnamoylneoline, a new alkaloid from the flower buds of Aconitum carmichaeli and its toxic and analgesic activities [J].

Taki, M ;

Niitu, K ;

Omiya, Y ;

Noguchi, M ;

Fukuchi, M ;

Aburada, M ;

Okada, M .

PLANTA MEDICA, 2003, 69 (09) :800-803

[4]

Enzymatic glycosylation of contulakin-G, a glycopeptide isolated from Conus venom, with a mammalian ppGalNAc-transferase [J].

Craig, AG ;

Park, M ;

Fischer, WH ;

Kang, J ;

Compain, P ;

Piller, F .

TOXICON, 2001, 39 (06) :809-815

[5]

Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis [J].

Nakamura, M ;

Chi, YM ;

Yan, WM ;

Yonezawa, A ;

Nakasugi, Y ;

Yoshizawa, T ;

Hashimoto, F ;

Kinjo, J ;

Nohara, T ;

Sakurada, S .

PLANTA MEDICA, 2001, 67 (02) :114-117

[6]

Analgesic activity of the lignans from Lychnophora ericoides [J].

Borsato, MLC ;

Grael, CFF ;

Souza, GEP ;

Lopes, NP .

PHYTOCHEMISTRY, 2000, 55 (07) :809-813

[7]

Antinociceptive substances from Incarvillea delavayi [J].

Nakamura, M ;

Kido, K ;

Kinjo, J ;

Nohara, T .

PHYTOCHEMISTRY, 2000, 53 (02) :253-256

[8]

Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba [J].

de Miranda, ALP ;

Silva, JRA ;

Rezende, CM ;

Neves, JS ;

Parrini, SC ;

Pinheiro, MLB ;

Cordeiro, MC ;

Tamborini, E ;

Pinto, AC .

PLANTA MEDICA, 2000, 66 (03) :284-286

[9]

Novel analgesic triglycerides from cultures of Agaricus macrosporus and Basidiomycetes as selective inhibitors of neurolysin..Stadler M;Hellwig V;Mayer Bartschmid A. et al;.Journal of Antibiotics.2005, 12

[10]

Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands..Takayama H; Ishikawa H; Kurihara M; et al;.J Med Chem.2002,

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