肺癌分子诊断学研究进展

被引：7

作者：

薛剑

娄加陶

机构：

[1] 上海交通大学附属胸科医院检验科

来源：

上海交通大学学报(医学版) | 2011年 / 31卷 / 03期

关键词：

基因突变; 靶向治疗; miRNA; 肿瘤干细胞; 甲基化;

D O I：

暂无

中图分类号：

R734.2 [肺肿瘤];

学科分类号：

100214 ;

摘要：

肺癌的分子诊断作为影像学和细胞学筛查策略的重要补充,其内容不仅包括早期诊断,还包括预后指标及靶向治疗的预测等。该文拟对当前肺癌分子诊断的研究热点基因突变与靶向治疗预测、miRNA、肿瘤干细胞、甲基化及相关检测方法进行综述。

引用

页码：373 / 377

页数：5

共 9 条

[1] Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR [J].

Markou, Athina ;

Tsaroucha, Emily G. ;

Kaklamanis, Loukas ;

Fotinou, Marianthi ;

Georgoulias, Vassilis ;

Lianidou, Evi S. .

CLINICAL CHEMISTRY, 2008, 54 (10) :1696-1704

[2] MicroRNA signature predicts survival and relapse in lung cancer [J].

Yu, Sung-Liang ;

Chen, Hsuan-Yu ;

Chang, Gee-Chen ;

Chen, Chih-Yi ;

Chen, Huei-Wen ;

Singh, Sher ;

Cheng, Chiou-Ling ;

Yu, Chong-Jen ;

Lee, Yung-Chie ;

Chen, Han-Shiang ;

Su, Te-Jen ;

Chiang, Ching-Cheng ;

Li, Han-Ni ;

Hong, Qi-Sheng ;

Su, Hsin-Yuan ;

Chen, Chun-Chieh ;

Chen, Wan-Jiun ;

Liu, Chun-Chi ;

Chan, Wing-Kai ;

Chen, Wei J. ;

Li, Ker-Chau ;

Chen, Jeremy J. W. ;

Yang, Pan-Chyr .

CANCER CELL, 2008, 13 (01) :48-57

[3] The let-7 family of microRNAs [J].

Roush, Sarah ;

Slack, Frank J. .

TRENDS IN CELL BIOLOGY, 2008, 18 (10) :505-516

[4] microRNA and stem cell function [J].

Hatfield, Steven ;

Ruohola-Baker, Hannele .

CELL AND TISSUE RESEARCH, 2008, 331 (01) :57-66

[5] Wnt inhibitory factor inhibits lung cancer cell growth [J].

Kim, Jae ;

You, Liang ;

Xu, Zhidong ;

Kuchenbecker, Kris ;

Raz, Dan ;

He, Biao ;

Jablons, David .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2007, 133 (03) :733-737

[6] Unique microRNA molecular profiles in lung cancer diagnosis and prognosis [J].

Yanaihara, N ;

Caplen, N ;

Bowman, E ;

Seike, M ;

Kumamoto, K ;

Yi, M ;

Stephens, RM ;

Okamoto, A ;

Yokota, J ;

Tanaka, T ;

Colin, GA ;

Liu, CG ;

Croce, CM ;

Harris, CC .

CANCER CELL, 2006, 9 (03) :189-198

[7] RAS is regulated by the let-7 MicroRNA family [J].

Johnson, SM ;

Grosshans, H ;

Shingara, J ;

Byrom, M ;

Jarvis, R ;

Cheng, A ;

Labourier, E ;

Reinert, KL ;

Brown, D ;

Slack, FJ .

CELL, 2005, 120 (05) :635-647

[8] Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain [J].

Pao, W ;

Miller, VA ;

Politi, KA ;

Riely, GJ ;

Somwar, R ;

Zakowski, MF ;

Kris, MG ;

Varmus, H .

PLOS MEDICINE, 2005, 2 (03) :225-235

[9] Global cancer statistics in the year 2000 [J].

Parkin, DM .

LANCET ONCOLOGY, 2001, 2 (09) :533-543

← 1 →