“骨肉不相亲”理论指导下肌抑素在肌少-骨质疏松症中的机制探讨

被引：13

作者：

郑浩 ^{[1
]}

戚晓楠 ^{[2
]}

姚啸生 ^{[2
]}

机构：

[1] 辽宁中医药大学

[2] 辽宁中医药大学附属医院

来源：

中国骨质疏松杂志 | 2021年 / 27卷 / 11期

基金：

国家重点研发计划;

关键词：

中医中药; 骨肉不相亲; 肌肉生长抑制素; 肌少-骨质疏松症; 骨; 骨骼肌;

D O I：

暂无

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

随着人口老龄化的日益加剧,"肌少-骨质疏松症"(sarco-osteopenia)这类肌肉及骨协同退变的疾病日益增多,给社会带来巨大负担。中医很早就对肌骨协同退变疾病进行了记录,其中"骨肉不相亲"理论是中医学对肌骨协同退变病理机制的高度概括。近年研究发现,肌肉生长抑制素(Myostatin)由骨骼肌分泌,通过多条途径参与了骨骼肌和骨组织生长代谢的调节过程,可能成为肌骨之间调节的重要因子。笔者在"骨肉不相亲"理论的指导下,通过探究肌肉生长抑制素调控骨骼肌与骨代谢的机制,以期揭示肌少-骨质疏松症的病理机制,探索中医理论的现代医学实质,为该类疾病的防治提供新的思路。

引用

收藏

页码：1675 / 1680+1693 +1693

页数：7

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