缬沙坦与氨氯地平联合用药治疗原发性高血压的疗效

被引：12

作者：

周邠玮

袁毅

毕莹

王飞

段佳佳

刘新林

赵季红

机构：

[1] 武警后勤学院附属医院心脏医院

来源：

武警医学 | 2014年 / 25卷 / 08期

关键词：

缬沙坦; 氨氯地平; 原发性高血压; 联合用药;

D O I：

10.14010/j.cnki.wjyx.2014.08.011

中图分类号：

R544.1 [高血压];

学科分类号：

100201 [内科学];

摘要：

目的探讨缬沙坦联合氨氯地平不同用药方式和服药时间,治疗原发性高血压的疗效。方法 201例原发性高血压患者(男92例,女109例),接受缬沙坦(80 mg/d)联合氨氯地平(5 mg/d)治疗,随机分为四组,各组治疗方案如下:A组两种药物均于清晨服用,B组两种药物均于睡前服用,C组缬沙坦清晨服用、氨氯地平睡前服用,D组氨氯地平清晨服用、缬沙坦睡前服用。监测各组服药前及服药后12周的24 h动态血压值。结果服药12周后,各组血压指标均较治疗前下降,差异有统计学意义(P<0.05)。B组服药后各血压指标下降幅度明显低于其他三组,其中24 h SBP/DBP平均值分别为A组(123.0±13.2)mmHg/(73.1±6.7)mmHg、B组(113.6±11.0)mmHg/(67.1±8.3)mmHg、C组(124.4±13.7)mmHg/(73.6±9.0)mmHg、D组(119.8±13.0)mmHg/(70.6±7.2)mmHg,差异有统计学意义(P<0.01)。结论缬沙坦与氨氯地平睡前联合服用,治疗原发性高血压的效果最佳。

引用

页码：774 / 776+779 +779

页数：4

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