姜黄素治疗类风湿关节炎作用机制研究进展

被引：14

作者：

孙焱

于慧敏

机构：

[1] 哈尔滨医科大学附属第二医院中医科

来源：

中医药学报 | 2015年 / 43卷 / 06期

关键词：

类风湿; 姜黄素; 细胞因子; 成纤维样滑膜细胞;

D O I：

10.19664/j.cnki.1002-2392.2015.06.038

中图分类号：

R259 [现代医学内科疾病];

学科分类号：

100201 [内科学];

摘要：

类风湿关节炎是一种慢性自身免疫性疾病,其发病机理尚不明确。目前姜黄素已成为治疗类风湿的研究热点,本文针对近几年姜黄素治疗类风湿关节炎的作用机制进行总结,分别从其抗炎性及对自身细胞组织的影响两方面进行阐述。希望在类风湿关节炎的治疗上进一步拓宽思路。

引用

页码：113 / 116

页数：4

共 24 条

[1]

Curcumin Suppresses the Production of Pro-inflammatory Cytokine Interleukin-18 in Lipopolysaccharide Stimulated Murine Macrophage-Like Cells [J].

Yadav R. ;

Jee B. ;

Awasthi S.K. .

Indian Journal of Clinical Biochemistry, 2015, 30 (1) :109-112

[2]

Modulation of apoptosis-related cell signalling pathways by curcumin as a strategy to inhibit tumor progression [J].

Chen, Jin ;

Wang, Feng-Ling ;

Chen, Wei-Dong .

MOLECULAR BIOLOGY REPORTS, 2014, 41 (07) :4583-4594

[3]

In vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (VEGF, CyclinD1 and CDK4) in liver of rats injected with DEN [J].

Huang, Chu Zhu ;

Huang, Wei Zhe ;

Zhang, Ge ;

Tang, Dan Ling .

MOLECULAR BIOLOGY REPORTS, 2013, 40 (10) :5825-5831

[4]

Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes [J].

Kloesch, Burkhard ;

Becker, Tatjana ;

Dietersdorfer, Elisabeth ;

Kiener, Hans ;

Steiner, Guenter .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2013, 15 (02) :400-405

[5]

IL-18 Upregulates the Production of Key Regulators of Osteoclastogenesis from Fibroblast-Like Synoviocytes in Rheumatoid Arthritis [J].

Zhang, Wei ;

Cong, Xiao-Liang ;

Qin, Yang-Hua ;

He, Zheng-Wen ;

He, Dong-Yi ;

Dai, Sheng-Ming .

INFLAMMATION, 2013, 36 (01) :103-109

[6]

Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis.[J].BeatrixBartok;Gary S.Firestein.Immunological Reviews.2009, 1

[7]

Curcumin Decreased Oxidative Stress; Inhibited NF- κ B Activation; and Improved Liver Pathology in Ethanol-Induced Liver Injury in Rats.[J].Suchittra Samuhasaneeto;Duangporn Thong-Ngam;Onanong Kulaputana;Doungsamon Suyasunanont;Naruemon Klaikeaw;Stelvio M. Bandiera.Journal of Biomedicine and Biotechnology.2009,

[8]

Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated IκB kinase [J].