乙酰胆碱酯酶及其中药抑制剂的研究进展

被引：8

作者：

吴怀秀 ^{[1
]}

李彤彤 ^{[1
,2
]}

高飞 ^{[1
]}

钱永常 ^{[1
]}

王向军 ^{[1
]}

机构：

[1] 浙江农林大学林业与生物技术学院亚热带森林培育国家重点实验室培育基地

[2] 云南农业大学农学与生物技术学院

来源：

药物生物技术 | 2015年 / 22卷 / 04期

关键词：

乙酰胆碱酯酶; 抑制剂; 阿尔茨海默病; 天然产物; 进展;

D O I：

10.19526/j.cnki.1005-8915.2015.04.019

中图分类号：

R284 [中药化学]; R285 [中药药理学];

学科分类号：

100804 [中药化学]; 100806 [中药药理学];

摘要：

乙酰胆碱水平降低或活性异常是阿尔茨海默病发生的主要原因,通过抑制乙酰胆碱酯酶的活性,提高乙酰胆碱水平可以治疗阿尔茨海默病。因此乙酰胆碱酯酶抑制剂成为目前治疗阿尔茨海默病最有效的方法之一。近年来,从天然产物及其衍生物中筛选中药抑制剂备受关注。文章综述了近年来重组人乙酰胆碱酯酶及其中药抑制剂的研究现状。

引用

页码：362 / 365

页数：4

共 22 条

[1]

Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease [J].

Romero, Alejandro ;

Cacabelos, Ramon ;

Oset-Gasque, Maria J. ;

Samadi, Abdelouahid ;

Marco-Contelles, Jose .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (07) :1916-1922

[2]

Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis [J].

Hung, Tran Manh ;

Na, MinKyun ;

Min, Byung Sun ;

Ngoc, Tran Minh ;

Lee, IkSoo ;

Zhang, XinFeng ;

Bae, KiHwan .

ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (06) :685-690

[3]

Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties [J].

Choudhary, MI ;

Nawaz, SA ;

ul-Haq, Z ;

Lodhi, MA ;

Ghayur, MN ;

Jalil, S ;

Riaz, N ;

Yousuf, S ;

Malik, A ;

Gilani, AH ;

Atta-ur-Rahman .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (01) :276-287

[4]

Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza [J].

Ren, YH ;

Houghton, PJ ;

Hider, RC ;

Howes, MJR .

PLANTA MEDICA, 2004, 70 (03) :201-204

[5]

Treatment of Alzheimer's disease: current status and new perspectives [J].

Scarpini, E ;

Scheltens, P ;

Feldman, H .

LANCET NEUROLOGY, 2003, 2 (09) :539-547

[6]

Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies.[J].Kornkanok Ingkaninan;Prapapan Temkitthawon;Kanchanaporn Chuenchom;Thitaree Yuyaem;Warawit Thongnoi.Journal of Ethnopharmacology.2003, 2

[7]

Acetylcholinesterase inhibitors from the roots of Angelica dahurica [J].

Kim, DK ;

Lim, JP ;

Yang, JH ;

Eom, DO ;

Eun, JS ;

Leem, KH .

ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (06) :856-859

[8]

A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba.[J].Amitava Das;Girja Shanker;Chandishwar Nath;Raghwendra Pal;Satyawan Singh;Hemant K Singh.Pharmacology; Biochemistry and Behavior.2002, 4

[9]

Inhibition of acetylcholinesterase activity by essential oil from Citrus paradisi [J].