Synthesis of [4,5-bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as potential inhibitors of HIV

被引：19

作者：

Branalt, J

Kvarnstrom, I

Classon, B

Samuelsson, B

机构：

[1] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN

[2] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 11期

关键词：

D O I：

10.1021/jo960008k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1,3-dioxolan-2-ylnucleosides and related chemistry is described. We have shown that 2-methoxy-1,3-dioxolane (6) reacts with silylated thymine and trimethylsilyl triflate to give the acyclic formate ester 1-[2-(formyloxy)ethyl]thymine (8) rather than 1-(1,3-dioxolan-2-yl)thymine (7). A tentative mechanism which could explain this result is discussed. On the other hand, 2-methoxy-1,3-dioxolane 13c reacts with silylated bases to give [4,5-bis(hydroxymethyl)-1,3-dioxolan2-yl]nucleosides, thus representing the first examples of this novel class of compounds. The nature of the nucleobase and the hydroxyl protecting groups was found to have great influence on the reaction and on the stability of the nucleosides. Compounds 16 and 18 were found to be inactive when tested for anti HIV-1 activity in vitro.

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页码：3599 / 3603

页数：5

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