Co-Metal-Free Enantioselective Conjugate Addition Reactions of Zinc Reagents

被引：27

作者：

Ay, Sefer ^{[1
]}

Nieger, Martin ^{[2
]}

Braese, Stefan ^{[1
]}

机构：

[1] Univ Karlsruhe, Inst Organ Chem, D-76131 Karlsruhe, Germany

[2] Univ Helsinki, Inorgan Chem Lab, FIN-00014 Helsinki, Finland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 36期

关键词：

asymmetric catalysis; conjugate addition reactions; enals; N; O-ligands; organozinc reagents;

D O I：

10.1002/chem.200801676

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric conjugate addition of diethylzine to cinnamaldehyde in a co-metal-free fashion by using N,O-ligands with planar and central chirality is described. Different modulations of the ligand structure, including several combinations of the chiral units. indicate that a [2.2]paracyclophane backbone is essential for the activity and the enantioselectivity of the generated active catalyst. By using the optimized ligand, an isolated yield of 90% was obtained with up to 99% ee.

引用

页码：11539 / 11556

页数：18

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