Asymmetric conjugate addition to alkylidene malonates

被引：64

作者：

Alexakis, A ^{[1
]}

Benhaim, C ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(01)00196-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Dialkylzinc and trialkylaluminium reagents undergo conjugate addition to alkylidene malonates with 0.5% copper triflate as catalyst. The reaction could be made enantioselective by completing the reaction in the presence of 0.5-1.0 mol% of chiral phosphorus ligand. Enantiomeric excesses (e.e.s) of up to 73% could br attained with a ligand prepared from TADDOL and 2-naphthylcyclohexanol. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1151 / 1157

页数：7

共 32 条

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