A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261

被引：17

作者：

Bressan, RA

Erlandsson, K ^{[1
]}

Mulligan, RS

Gunn, RN

Cunningham, VJ

Owens, J

Cullum, ID

Ell, PJ

Pilowsky, LS

机构：

[1] UCL Med Sch, Inst Nucl Med, London, England

[2] Inst Psychiat, London SE5 8AF, England

[3] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[4] Hammersmith Hosp, IRSL, London W12 0NN, England

[5] Univ Glasgow, Western Infirm, W Scotland Radionucl Dispensary, Glasgow G11 6NT, Lanark, Scotland

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 02期

基金：

英国医学研究理事会;

关键词：

NMDA receptors; dynamic SPET; kinetic modeling; constant infusion; equilibrium analysis; volume of distribution;

D O I：

10.1016/j.nucmedbio.2003.08.008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We have previously performed quantitative kinetic modeling of [I-123] CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [I-123]CNS 1261 in clinical populations. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：155 / 164

页数：10

共 22 条

[1] PET studies of 18F-memantine in healthy volunteers [J].