Clinical Pharmacogenetics Implementation Consortium Guidelines for Human Leukocyte Antigen-B Genotype and Allopurinol Dosing

被引：193

作者：

Hershfield, M. S. ^{[1
,2
]}

Callaghan, J. T. ^{[3
,4
,5
]}

Tassaneeyakul, W. ^{[6
]}

Mushiroda, T. ^{[7
]}

Thorn, C. F. ^{[8
]}

Klein, T. E. ^{[8
]}

Lee, M. T. M. ^{[9
,10
,11
]}

机构：

[1] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA

[2] Duke Univ, Sch Med, Dept Biochem, Durham, NC USA

[3] Dept Vet Affairs Med Ctr, ACOS Res, Indianapolis, IN USA

[4] Indiana Univ Sch Med, Dept Med, Indianapolis, IN USA

[5] Indiana Univ Sch Med, Dept Pharmacol Toxicol, Indianapolis, IN USA

[6] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen, Thailand

[7] RIKEN, Ctr Genom Med, Lab Pharmacogenet, Yokohama, Kanagawa, Japan

[8] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA

[9] Acad Sinica, Inst Biomed Sci, Natl Ctr Genome Med, Taipei, Taiwan

[10] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[11] RIKEN, Ctr Genom Med, Lab Int Alliance, Yokohama, Kanagawa, Japan

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2013年 / 93卷 / 02期

基金：

美国国家卫生研究院;

关键词：

STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; GENOME-WIDE ASSOCIATION; HLA-B; RISK-FACTOR; GOUT; HEALTH; HYPERSENSITIVITY; PREVALENCE; HLA-B-ASTERISK-5801;

D O I：

10.1038/clpt.2012.209

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout. However, allopurinol is also one of the most common causes of severe cutaneous adverse reactions (SCARs), which include drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. A variant allele of the human leukocyte antigen (HLA)-B, HLA-B*58:01, associates strongly with allopurinol-induced SCAR. We have summarized the evidence from the published literature and developed peer-reviewed guidelines for allopurinol use based on HLA-B genotype.

引用

页码：153 / 158

页数：6

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