Angiogenesis in the mouse retina: A model system for experimental manipulation

被引：65

作者：

Uemura, AK ^{[1
]}

Kusuhara, S ^{[1
]}

Katsuta, H ^{[1
]}

Nishikawa, S ^{[1
]}

机构：

[1] RIKEN, Ctr Dev Biol, Lab Stem Cell Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

EXPERIMENTAL CELL RESEARCH | 2006年 / 312卷 / 05期

关键词：

angiogenesis; retina; manipulation;

D O I：

10.1016/j.yexcr.2005.10.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The vascular system of the mouse retina provides a useful model for analyzing the molecular and cellular mechanisms regulating angiogenesis because (1) hierarchical vascular networks are newly formed only after birth, (2) the cellular components involved in angiogenesis are well characterized, and (3) all the processes are accessible for monitoring and manipulation. In this article, we present an overview of our current understanding of the process of retinal angiogenesis and describe a number of methodologies applicable to experimental manipulation of the retinal vascular system. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：676 / 683

页数：8

共 42 条

[31] Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice [J].

Schlaeger, TM ;

Bartunkova, S ;

Lawitts, JA ;

Teichmann, G ;

Risau, W ;

Deutsch, U ;

Sato, TN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3058-3063

[32] RETINAL ASTROCYTES - THEIR RESTRICTION TO VASCULARIZED PARTS OF THE MAMMALIAN RETINA [J].

SCHNITZER, J .

NEUROSCIENCE LETTERS, 1987, 78 (01) :29-34

[33] ASTROCYTES IN THE GUINEA-PIG, HORSE, AND MONKEY RETINA - THEIR OCCURRENCE COINCIDES WITH THE PRESENCE OF BLOOD-VESSELS [J].

SCHNITZER, J .

GLIA, 1988, 1 (01) :74-89

[34]

SMITH LEH, 1994, INVEST OPHTH VIS SCI, V35, P101

[35] DEVELOPMENT OF RETINAL VASCULATURE IS MEDIATED BY HYPOXIA-INDUCED VASCULAR ENDOTHELIAL GROWTH-FACTOR (VEGF) EXPRESSION BY NEUROGLIA [J].

STONE, J ;

ITIN, A ;

ALON, T ;

PEER, J ;

GNESSIN, H ;

CHANLING, T ;

KESHET, E .

JOURNAL OF NEUROSCIENCE, 1995, 15 (07) :4738-4747

[36] Requisite role of Angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis [J].

Suri, C ;

Jones, PF ;

Patan, S ;

Bartunkova, S ;

Maisonpierre, PC ;

Davis, S ;

Sato, TN ;

Yancopoulos, GD .

CELL, 1996, 87 (07) :1171-1180

[37] Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1 [J].

Thurston, G ;

Suri, C ;

Smith, K ;

McClain, J ;

Sato, TN ;

Yancopoulos, GD ;

McDonald, DM .

SCIENCE, 1999, 286 (5449) :2511-2514

[38] Molecular distinction between arteries and veins [J].

Torres-Vaázquez, J ;

Kamei, M ;

Weinstein, BM .

CELL AND TISSUE RESEARCH, 2003, 314 (01) :43-59

[39] Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells [J].

Uemura, A ;

Ogawa, M ;

Hirashima, M ;

Fujiwara, T ;

Koyama, S ;

Takagi, H ;

Honda, Y ;

Wiegand, SJ ;

Yancopoulos, GD ;

Nishikawa, SI .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (11) :1619-1628

[40] Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4 [J].

Wang, HU ;

Chen, ZF ;

Anderson, DJ .

CELL, 1998, 93 (05) :741-753

← 1 2 3 4 5 →