An Efficient and Practical Sequential One-Pot Synthesis of Suprofen, Ketoprofen and Other 2-Arylpropionic Acids

被引：75

作者：

Neumann, Helfried ^{[1
]}

Brennfuehrer, Anne ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 14-15期

关键词：

homogeneous catalysis; hydroxycarbonylation; palladium; profenes; Suzuki carbonylation;

D O I：

10.1002/adsc.200800415

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxy-carbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium (R) A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.

引用

页码：2437 / 2442

页数：6

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