A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxy-carbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium (R) A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.