An Efficient and Practical Sequential One-Pot Synthesis of Suprofen, Ketoprofen and Other 2-Arylpropionic Acids

被引:75
作者
Neumann, Helfried [1 ]
Brennfuehrer, Anne [1 ]
Beller, Matthias [1 ]
机构
[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
关键词
homogeneous catalysis; hydroxycarbonylation; palladium; profenes; Suzuki carbonylation;
D O I
10.1002/adsc.200800415
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A novel sequential double carbonylation to synthesize anti-inflammatory drugs such as Ketoprofen and Suprofen has been developed. Starting from easily available aryl halides and arylboronic acids a one-pot carbonylative Suzuki and hydroxy-carbonylation reaction sequence proceeds in good selectivity and high yield in the presence of the palladium/cataCXium (R) A catalyst system. Applying optimized conditions different 2-arylpropionic acids were synthesized in good yields.
引用
收藏
页码:2437 / 2442
页数:6
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