Adipose tissue as source and target for novel therapies

被引：41

作者：

Klein, J

Perwitz, N

Kraus, D

Fasshauer, M

机构：

[1] Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany

[2] Univ Leipzig, Dept Internal Med 3, D-04103 Leipzig, Germany

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.tem.2005.11.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

引用

收藏

页码：26 / 32

页数：7

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