Desosamine in multicomponent reactions

被引：25

作者：

Achatz, Sepp

Doemling, Alexander

机构：

[1] ABC Pharma, D-81243 Munich, Germany

[2] Morphochem AG, D-81379 Munich, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 24期

关键词：

desosamine; ribosome; antibiotic; multicomponent reaction; isocyanide; tetrazole;

D O I：

10.1016/j.bmcl.2006.07.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ubiquitously in natural products occurring desosarnine is introduced into isocyanide based multicomponent reaction chemistry. Corresponding products are of potential interest for the design of novel antibiotics. (c) 2006 Published by Elsevier Ltd.

引用

页码：6360 / 6362

页数：3

共 28 条

[1] Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold [J].

Antuch, W ;

Menon, S ;

Chen, QZ ;

Lu, YC ;

Sakamuri, S ;

Beck, B ;

Schauer-Vukasinovic, V ;

Agarwal, S ;

Hess, S ;

Dömling, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (06) :1740-1743

[2] A novel three-component butenolide synthesis [J].

Beck, B ;

Magnin-Lachaux, M ;

Herdtweck, E ;

Dömling, A .

ORGANIC LETTERS, 2001, 3 (18) :2875-2878

[3] One-pot synthesis and biological evaluation of aspergillamides and analogues [J].

Beck, B ;

Hess, S ;

Dömling, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) :1701-1705

[4] Highly substituted pyrrolidinones and pyridones by 4-CR/2-CR sequence [J].

Beck, B ;

Picard, A ;

Herdtweck, E ;

Dömling, A .

ORGANIC LETTERS, 2004, 6 (01) :39-42

[5]

Bienaymé H, 2000, CHEM-EUR J, V6, P3321, DOI 10.1002/1521-3765(20000915)6:18<3321::AID-CHEM3321>3.0.CO

[6]

2-A

[7] Cyanamide in isocyanide-based MCRs [J].

Dömling, A ;

Herdtweck, E ;

Heck, S .

TETRAHEDRON LETTERS, 2006, 47 (11) :1745-1747

[8] Recent developments in isocyanide based multicomponent reactions in applied chemistry [J].

Dömling, A .

CHEMICAL REVIEWS, 2006, 106 (01) :17-89

[9]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[10]

2-U

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