Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT

被引：146

作者：

Gary-Bobo, Magali ^{[4
]}

Hocine, Ouahiba ^{[3
]}

Brevet, David ^{[3
]}

Maynadier, Marie ^{[4
]}

Raehm, Laurence ^{[3
]}

Richeter, Sebastien ^{[3
]}

Charasson, Virginie ^{[4
]}

Loock, Bernard ^{[5
,6
]}

Morere, Alain ^{[1
,2
]}

Maillard, Philippe ^{[5
,6
]}

Garcia, Marcel ^{[4
]}

Durand, Jean-Olivier ^{[3
]}

机构：

[1] Ecole Natl Super Chim Montpellier, CNRS, UMR 5247, UM2, F-34296 Montpellier, France

[2] Ecole Natl Super Chim Montpellier, Inst Biomol Max Mousseron, UM1, F-34296 Montpellier, France

[3] Inst Charles Gerhardt Montpellier, CNRS, ENSCM, UMR 5253,UM2,UM1,Equipe Chim Mol & Org Saude CC17, F-34095 Montpellier 05, France

[4] Fac Pharm Montpellier, Inst Biomol Max Mousseron, F-34093 Montpellier, France

[5] Univ Paris 11, Inst Curie, CNRS, UMR 176, F-91405 Orsay, France

[6] Ecole Natl Super Chim Montpellier, Ctr Univ, Sect Rech, Inst Curie, F-34296 Montpellier, France

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 423卷 / 02期

关键词：

Mesoporous; Silica; Nanoparticles; Photodynamic therapy; Targeting; Drug delivery; Carbohydrates; CONTROLLED-RELEASE; PHOTODYNAMIC THERAPY; FOLIC-ACID; CELLS; FUNCTIONALIZATION; CAMPTOTHECIN; DOXORUBICIN; SYSTEM; BIODISTRIBUTION; EFFICIENCY;

D O I：

10.1016/j.ijpharm.2011.11.045

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The synthesis of Mesoporous Silica Nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anticancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：509 / 515

页数：7

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