Silica-based nanoparticles for photodynamic therapy applications

被引：234

作者：

Couleaud, Pierre ^{[2
]}

Morosini, Vincent ^{[3
]}

Frochot, Celine ^{[2
]}

Richeter, Sebastien ^{[1
]}

Raehm, Laurence ^{[1
]}

Durand, Jean-Olivier ^{[1
]}

机构：

[1] UM2, ENSCM, UM1,Equipe Chim Mol & Org Solide, Inst Charles Gerhardt Montpellier,UMR 5253,CNRS, F-34095 Montpellier 05, France

[2] Univ Nancy 1, Lab React & Genie Procedes, UPR 3349, F-54000 Nancy, France

[3] Nancy Univ, CNRS, Ctr Alexis Vautrin, CRAN,UMR 7039, Vandoeuvre Les Nancy, France

来源：

NANOSCALE | 2010年 / 2卷 / 07期

关键词：

PHOTOSENSITIZER; CARRIER; DRUG; MECHANISMS; DELIVERY; SYSTEM;

D O I：

10.1039/c0nr00096e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Silica-based nanoparticles for applications in photodynamic therapy (PDT) have emerged as a promising field for the treatment of cancer. In this review, based on the pathway the photosensitizer is entrapped inside the silica matrix, the different methods for the synthesis of silica-based nanoparticles are described from the pioneering works to the latest achievements which concern multifunctional nanoplatforms, up-converting nanoparticles, two-photon PDT, vectorization and in vivo applications.

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页码：1083 / 1095

页数：13

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