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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

被引：966
作者：
Schoepp, DD
Jane, DE
Monn, JA
机构：
[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA
[2] Univ Bristol, Sch Med Sci, Dept Pharmacol, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England
来源：
NEUROPHARMACOLOGY | 1999年 / 38卷 / 10期
关键词：
metabotropic; glutamate; pharmacology; mGlu receptors; excitatory amino acid;
D O I：
10.1016/S0028-3908(99)00092-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1431 / 1476
页数：46
相关论文
共 270 条
  • [91] 3,5-DIHYDROXYPHENYLGLYCINE - A POTENT AGONIST OF METABOTROPIC GLUTAMATE RECEPTORS
    ITO, I
    KOHDA, A
    TANABE, S
    HIROSE, E
    HAYASHI, M
    MITSUNAGA, S
    SUGIYAMA, H
    [J]. NEUROREPORT, 1992, 3 (11) : 1013 - 1016
  • [92] STEREOSPECIFIC ANTAGONISM BY (+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE (MCPG) OF (1S,3R)-ACPD-INDUCED EFFECTS IN NEONATAL RAT MOTONEURONS AND RAT THALAMIC NEURONS
    JANE, DE
    JONES, PLS
    POOK, PCK
    SALT, TE
    SUNTER, DC
    WATKINS, JC
    [J]. NEUROPHARMACOLOGY, 1993, 32 (07) : 725 - 727
  • [93] Jane DE, 1996, PHOSPHORUS SULFUR, V109, P313
  • [94] JANE DE, 1994, BRIT J PHARMACOL, V112, P809
  • [95] NEW PHENYLGLYCINE DERIVATIVES WITH POTENT AND SELECTIVE ANTAGONIST ACTIVITY AT PRESYNAPTIC GLUTAMATE RECEPTORS IN NEONATAL RAT SPINAL-CORD
    JANE, DE
    PITTAWAY, K
    SUNTER, DC
    THOMAS, NK
    WATKINS, JC
    [J]. NEUROPHARMACOLOGY, 1995, 34 (08) : 851 - 856
  • [96] Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord
    Jane, DE
    Thomas, NK
    Tse, HW
    Watkins, JC
    [J]. NEUROPHARMACOLOGY, 1996, 35 (08) : 1029 - 1035
  • [97] JOHANSEN PA, 1995, MOL PHARMACOL, V48, P140
  • [98] IDENTIFICATION OF 2-AMINO-2-METHYL-4-PHOSPHONOBUTANOIC ACID AS AN ANTAGONIST AT THE MGLU(4A) RECEPTOR
    JOHANSEN, PA
    ROBINSON, MB
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1995, 290 (02): : R1 - R3
  • [99] [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors:: characterization of binding to membranes of mGlu receptor subtype expressing cells
    Johnson, BG
    Wright, RA
    Arnold, MB
    Wheeler, WJ
    Ornstein, PL
    Schoepp, DD
    [J]. NEUROPHARMACOLOGY, 1999, 38 (10) : 1519 - 1529
  • [100] JOLY C, 1995, J NEUROSCI, V15, P3970
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