Pharmacological agents acting at subtypes of metabotropic glutamate receptors

被引：966

作者：

Schoepp, DD

Jane, DE

Monn, JA

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

[2] Univ Bristol, Sch Med Sci, Dept Pharmacol, MRC,Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

来源：

NEUROPHARMACOLOGY | 1999年 / 38卷 / 10期

关键词：

metabotropic; glutamate; pharmacology; mGlu receptors; excitatory amino acid;

D O I：

10.1016/S0028-3908(99)00092-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a recognized, but still relatively new area of excitatory amino acid research. Current understanding of the roles and involvement of mGlu receptor subtypes in physiological/pathophysiological functions of the central nervous system has been recently propelled by the emergence of various structurally novel, potent, and mGlu receptor selective pharmacological agents. This article reviews the evolution of pharmacological agents that have been reported to target mGlu receptors, with a focus on the known receptor subtype selectivities of current agents. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1431 / 1476

页数：46

共 270 条

[51] Antagonist activity of α-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells
Doherty, AJ
Collingridge, GL
Jane, DE
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (01) : 205 - 210
[52] (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus
Doherty, AJ
Palmer, MJ
Henley, JM
Collingridge, GL
Jane, DE
[J]. NEUROPHARMACOLOGY, 1997, 36 (02) : 265 - 267
[53] DUVOISIN RM, 1995, J NEUROSCI, V15, P3075
[54] COMPETITIVE ANTAGONISM AT METABOTROPIC GLUTAMATE RECEPTORS BY (S)-4-CARBOXYPHENYLGLYCINE AND (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
EATON, SA
JANE, DE
JONES, PLS
PORTER, RHP
POOK, PCK
SUNTER, DC
UDVARHELYI, PM
ROBERTS, PJ
SALT, TE
WATKINS, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1993, 244 (02): : 195 - 197
[55] IONOTROPIC AND METABOTROPIC NEUROTRANSMISSION
ECCLES, JC
MCGEER, PL
[J]. TRENDS IN NEUROSCIENCES, 1979, 2 (02) : 39 - 40
[56] Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3
Emile, L
Mercken, L
Apiou, F
Pradier, L
Bock, MD
Menager, J
Clot, J
Doble, A
Blanchard, JC
[J]. NEUROPHARMACOLOGY, 1996, 35 (05) : 523 - 530
[57] [H-3]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a
Eriksen, L
Thomsen, C
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1995, 116 (08) : 3279 - 3287
[58] (2S,4S)-2-amino-4-(2,2-diphenylethyl) pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist
Escribano, A
Ezquerra, J
Pedregal, C
Rubio, A
Yruretagoyena, B
Baker, SR
Wright, RA
Johnson, BG
Schoepp, DD
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (07) : 765 - 770
[59] Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor:: effects on cell surface expression, dimerization and signal transduction
Fan, GF
Ray, K
Zhao, XM
Goldsmith, PK
Spiegel, AM
[J]. FEBS LETTERS, 1998, 436 (03) : 353 - 356
[60] TRANS-AZETIDINE-2, 4-DICARBOXYLIC ACID ACTIVATES NEURONAL METABOTROPIC RECEPTORS
FAVARON, M
MANEV, RM
CANDEO, P
ARBAN, R
GABELLINI, N
KOZIKOWSKI, AP
MANEV, H
[J]. NEUROREPORT, 1993, 4 (07) : 967 - 970

← 1 2 3 4 5 6 7 8 9 10 →