Competing pathways in the oxidation of (Z)under-bar-3-ethylidine cephalosporin C by the enzyme deacetoxycephalosporin C synthase (DAOCS)

被引：2

作者：

Baldwin, JE ^{[1
]}

Adlington, RM ^{[1
]}

Crouch, NP ^{[1
]}

Hill, RL ^{[1
]}

Wood, ME ^{[1
]}

Lloyd, MD ^{[1
]}

机构：

[1] UNIV OXFORD,OXFORD CTR MOL SCI,OXFORD OX1 3QY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(97)00052-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

DAOCS converts (Z) under bar-3-ethylidene cephalosporin C to two diastereomeric alcohols in the ratio 7:2 with nearly complete incorporation of O-18 from O-18(2). (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：593 / 596

页数：4

共 6 条

[1] INCORPORATION OF O-18-LABELED WATER INTO OXYGENATED PRODUCTS PRODUCED BY THE ENZYME DEACETOXY DEACETYLCEPHALOSPORIN C-SYNTHASE [J].

BALDWIN, JE ;

ADLINGTON, RM ;

CROUCH, NP ;

PEREIRA, IAC .

TETRAHEDRON, 1993, 49 (34) :7499-7518

[2] WATER EXCHANGE OF INTERMEDIATES IN A NONHEME IRON, ALPHA-KETOGLUTARATE DIOXYGENASE, DEACETOXY- DEACETYLCEPHALOSPORIN C-SYNTHASE [J].

BALDWIN, JE ;

ADLINGTON, RM ;

CROUCH, NP ;

PEREIRA, IAC ;

APLIN, RT ;

ROBINSON, C .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (02) :105-108

[3] EPOXIDE FORMATION IN THE ENZYMATIC CONVERSION OF [4-H-2]EXOMETHYLENE CEPHALOSPORIN-C BY DEACETOXYCEPHALOSPORIN DEACETYLCEPHALOSPORIN-C SYNTHASE [J].

BALDWIN, JE ;

ADLINGTON, RM ;

CROUCH, NP ;

PEREIRA, IAC .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (19) :1448-1451

[4] EVIDENCE FOR EPOXIDASE ACTIVITY IN DEACETOXY DEACETYLCEPHALOSPORIN-C SYNTHASE [J].

BALDWIN, JE ;

ADLINGTON, RM ;

CROUCH, NP ;

PEREIRA, IAC .

TETRAHEDRON, 1993, 49 (22) :4907-4922

[5] SYNTHESIS OF 3-ALKYLIDENECEPHAM-4-CARBOXYLIC ACID-DERIVATIVES BY SAMARIUM(II) IODIDE REDUCTION [J].

KANG, HY ;

CHO, YS ;

KOH, HY ;

CHANG, MH .

SYNTHETIC COMMUNICATIONS, 1993, 23 (21) :2977-2984

[6]

WOOD ME, 1990, THESIS OXFORD U

← 1 →