A genetic hierarchy controlling cell polarity

被引:46
作者
Johnson, K [1 ]
Wodarz, A [1 ]
机构
[1] Univ Dusseldorf, Inst Genet, D-40225 Dusseldorf, Germany
关键词
D O I
10.1038/ncb0103-12
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The establishment and maintenance of apicobasal cell polarity is of fundamental importance for most physiological functions of epithelial tissues. In Drosophila melanogaster, several critical regulators of cell polarity have been identified over the past years, but we are just beginning to understand how these genes interact with each other. Two new papers now shed light on the genetic hierarchy that rules this process.
引用
收藏
页码:12 / 14
页数:3
相关论文
共 16 条
[11]   Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity [J].
Ohno, S .
CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) :641-648
[12]   DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila [J].
Petronczki, M ;
Knoblich, JA .
NATURE CELL BIOLOGY, 2001, 3 (01) :43-49
[13]   The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost [J].
Roh, MH ;
Makarova, O ;
Liu, CJ ;
Shin, K ;
Lee, S ;
Laurinec, S ;
Goyal, M ;
Wiggins, R ;
Margolis, B .
JOURNAL OF CELL BIOLOGY, 2002, 157 (01) :161-172
[14]   Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization [J].
Tanentzapf, G ;
Tepass, U .
NATURE CELL BIOLOGY, 2003, 5 (01) :46-52
[15]   Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts [J].
Wodarz, A ;
Ramrath, A ;
Grimm, A ;
Knust, E .
JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1361-1374
[16]   EXPRESSION OF CRUMBS CONFERS APICAL CHARACTER ON PLASMA-MEMBRANE DOMAINS OF ECTODERMAL EPITHELIA OF DROSOPHILA [J].
WODARZ, A ;
HINZ, U ;
ENGELBERT, M ;
KNUST, E .
CELL, 1995, 82 (01) :67-76