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Polarity and Differential Inheritance-Universal Attributes of Life?

被引：98
作者：
Macara, Ian G. [1 ]
Mili, Stavroula [1 ]
机构：
[1] Univ Virginia, Sch Med, Ctr Cell Signaling, Dept Microbiol, Charlottesville, VA 22908 USA
来源：
CELL | 2008年 / 135卷 / 05期
关键词：
D O I：
10.1016/j.cell.2008.11.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
When and why did cell polarization arise? Recent work in bacteria and yeast suggests that polarization may have evolved to restrict senescence to one daughter during division by enabling the differential segregation of damaged material. In more complex organisms, polarity functions have diversified to permit the differential inheritance of centrosomes, RNAs, proteins, and membranes, which is essential for the generation of diverse cell types from stem cells and for morphogenesis.
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收藏
页码：801 / 812
页数：12
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