Nitrative stress through formation of 8-nitroguanosine: Insights into microbial pathogenesis

被引：27

作者：

Akuta, T ^{[1
]}

Zaki, MH ^{[1
]}

Yoshitake, J ^{[1
]}

Okamoto, T ^{[1
]}

Akaike, T ^{[1
]}

机构：

[1] Kumamoto Univ, Dept Microbiol, Grad Sch Med Sci, Kumamoto 8608556, Japan

来源：

NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2006年 / 14卷 / 02期

关键词：

nitric oxide; nitrative stress; 3-nitrotyrosine; 8-nitroguanosine; viral pathogenesis; viral mutation;

D O I：

10.1016/j.niox.2005.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen and nitrogen species, respectively, mediate oxidative and nitrative stresses by means of oxidation and nitration of varions biomolecules including proteins, lipids, and nucleic acids. We have observed nitric oxide (NO)-dependent formation of 8-nitroguanosine and 3-nitrotyrosine during microbial infection, and we determined that both 8-nitroguanosine and 3-nitrotyrosine are useful biomarkers of nitrative stress. Of importance, however, is the great difference in biological characteristics of these two nitrated compounds. 8-Nitroguanosine has unique biochemical and pharmacological properties such as redox activity and mutagenic potential, which 3-nitrotyrosine does not. In this review, we discuss the mechanism of nitrative stress occurring during microbial infections, with special emphasis on biological functions of 8-nitroguanosine formed via NO during the host response to pathogens. These findings provide insights into NO-mediated pathogenesis not only of viral infections but also of many other diseases. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：101 / 108

页数：8

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