A bioabsorbable everolimus-eluting coronary stent system (ABSORB): 2-year outcomes and results from multiple imaging methods

被引:613
作者
Serruys, Patrick W. [1 ]
Ormiston, John A. [3 ]
Onuma, Yoshinobu [1 ]
Regar, Evelyn [1 ]
Gonzalo, Nieves [1 ]
Garcia-Garcia, Hector M. [4 ]
Nieman, Koen [1 ,2 ]
Bruining, Nico [1 ]
Dorange, Cecile [5 ]
Miquel-Hebert, Karine [5 ]
Veldhof, Susan [5 ]
Webster, Mark [3 ]
Thuesen, Leif [6 ]
Dudek, Dariusz [7 ]
机构
[1] Erasmus MC, Ctr Thorax, Rotterdam, Netherlands
[2] Erasmus MC, Dept Radiol, Rotterdam, Netherlands
[3] Auckland City Hosp, Auckland, New Zealand
[4] Cardialysis BV, Rotterdam, Netherlands
[5] Abbott Vasc, Diegem, Belgium
[6] Aarhus Univ Hosp, Skejby Sygehus, Skejby, Denmark
[7] Jagiellonian Univ, Krakow, Poland
关键词
ATHEROSCLEROTIC PLAQUE COMPOSITION; INTRAVASCULAR ULTRASOUND; ARTERY LESIONS; ANGIOPLASTY; TOMOGRAPHY; COVERAGE;
D O I
10.1016/S0140-6736(09)60325-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Drug-eluting metallic coronary stents predispose to late stent thrombosis, prevent late lumen vessel enlargement, hinder surgical revascularisation, and impair imaging with multislice CT. We assessed the safety of the bioabsorbable everolimus-eluting stent (BVS). Methods 30 patients with a single de-novo coronary artery lesion were followed up for 2 years clinically and with multiple imaging methods: multislice CT, angiography, intravascular ultrasound, derived morphology parameters (virtual histology, palpography, and echogenicity), and optical coherence tomography (OCT). Findings Clinical data were obtained from 29 of 30 patients. At 2 years, the device was safe with no cardiac deaths, ischaemia-driven target lesion revascularisations, or stent thromboses recorded, and only one myocardial infarction (non-Q wave). 18-month multislice CT (assessed in 25 patients) showed a mean diameter stenosis of 19% (SD 9). At 2-year angiography, the in-stent late loss of 0.48 mm (SD 0.28) and the diameter stenosis of 27% (11) did not differ from the findings at 6 months. The luminal area enlargement on OCT and intravascular ultrasound between 6 months and 2 years was due to a decrease in plaque size without change in vessel size. At 2 years, 34.5% of strut locations presented no discernible features by OCT, confirming decreases in echogenicity and in radiofrequency backscattering; the remaining apparent struts were fully apposed. Additionally, vasomotion occurred at the stented site and adjacent coronary artery in response to vasoactive agents. Interpretation At 2 years after implantation the stent was bioabsorbed, had vasomotion restored and restenosis prevented, and was clinically safe, suggesting freedom from late thrombosis. Late luminal enlargement due to plaque reduction without vessel remodelling needs confirmation.
引用
收藏
页码:897 / 910
页数:14
相关论文
共 43 条
  • [11] Novel magnetic resonance-compatible coronary stent -: The absorbable magnesium-alloy stent
    Eggebrecht, H
    Rodermann, J
    Hunold, P
    Schmermund, A
    Böse, D
    Haude, M
    Erbel, R
    [J]. CIRCULATION, 2005, 112 (18) : E303 - E304
  • [12] Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents:: a prospective, non-randomised multicentre trial
    Erbel, Raimund
    Di Mario, Carlo
    Bartunek, Jozef
    Bonnier, Johann
    de Bruyne, Bernard
    Eberli, Franz R.
    Erne, Paul
    Haude, Michael
    Heublein, Bernd
    Horrigan, Mark
    Ilsley, Charles
    Boese, Dirk
    Koolen, Jacques
    Luescher, Thomas F.
    Weissman, Neil
    Waksman, Ron
    [J]. LANCET, 2007, 369 (9576) : 1869 - 1875
  • [13] Pathological correlates of late drug-eluting stent thrombosis - Strut coverage as a marker of endothelialization
    Finn, Aloke V.
    Joner, Michael
    Nakazawa, Gaku
    Kolodgie, Frank
    Newell, John
    John, Mike C.
    Gold, Herman K.
    Virmani, Renu
    [J]. CIRCULATION, 2007, 115 (18) : 2435 - 2441
  • [14] QUANTITATIVE CORONARY ANGIOGRAPHY (QCA) IN INTERVENTIONAL CARDIOLOGY - CLINICAL-APPLICATION OF QCA MEASUREMENTS
    FOLEY, DP
    ESCANED, J
    STRAUSS, BH
    DIMARIO, C
    HAASE, J
    KEANE, D
    HERMANS, WRM
    RENSING, BJ
    DEFEYTER, PJ
    SERRUYS, PW
    [J]. PROGRESS IN CARDIOVASCULAR DISEASES, 1994, 36 (05) : 363 - 384
  • [15] Assessment of the absorption process following bioabsorbable everolimus-eluting stent implantation: temporal changes in strain values and tissue composition using intravascular ultrasound radiofrequency data analysis A substudy of the ABSORB clinical trial
    Garcia-Garcia, Hector M.
    Gonzalo, Nieves
    Pawar, Ravindra
    Kukreja, Neville
    Dudek, Dariusz
    Thuesen, Leif
    Ormiston, John A.
    Regar, Evelyn
    Serruys, Patrick W.
    [J]. EUROINTERVENTION, 2009, 4 (04) : 443 - 448
  • [16] CAN INTRACORONARY ULTRASOUND CORRECTLY ASSESS THE LUMINAL DIMENSIONS OF CORONARY-ARTERY LESIONS - A COMPARISON WITH QUANTITATIVE ANGIOGRAPHY
    HAASE, J
    OZAKI, Y
    DIMARIO, C
    ESCANED, J
    DEFEYTER, PJ
    ROELANDT, JRTC
    SERRUYS, PW
    [J]. EUROPEAN HEART JOURNAL, 1995, 16 (01) : 112 - 119
  • [17] Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation
    Hofma, SH
    van der Giessen, WJ
    van Dalen, BM
    Lemos, PA
    McFadden, EP
    Sianos, G
    Ligthart, JMR
    van Essen, D
    de Feyter, PJ
    Serruys, PW
    [J]. EUROPEAN HEART JOURNAL, 2006, 27 (02) : 166 - 170
  • [18] Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: Comparison with intravascular ultrasound
    Jang, IK
    Bouma, BE
    Kang, DH
    Park, SJ
    Park, SW
    Seung, KB
    Choi, KB
    Shishkov, M
    Schlendorf, K
    Pomerantsev, E
    Houser, SL
    Aretz, HT
    Tearney, GJ
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (04) : 604 - 609
  • [19] Incomplete neointimal coverage of sirolimus-eluting stents - Angioscopic findings
    Kotani, Jun-ichi
    Awata, Masaki
    Nanto, Shinsuke
    Uematsu, Masaaki
    Oshima, Fusako
    Minamiguchi, Hitoshi
    Mintz, Gary S.
    Nagata, Seiki
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (10) : 2108 - 2111
  • [20] PROLONGED CORONARY VASOCONSTRICTOR EFFECT OF ERGONOVINE MALEATE
    KURNIK, PB
    SPADARO, JJ
    NORDLICHT, SM
    TIEFENBRUNN, AJ
    LUDBROOK, PA
    [J]. CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS, 1984, 10 (04): : 353 - 361