Clickity-click: highly functionalized peptoid oligomers generated by sequential conjugation reactions on solid-phase support

被引：90

作者：

Holub, JM ^{[1
]}

Jang, HJ ^{[1
]}

Kirshenbaum, K ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 08期

关键词：

D O I：

10.1039/b518247f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Substituted glycine peptoid oligomers were used as substrates for azide-alkyne [ 3 + 2] cycloaddition conjugation reactions and then elaborated through additional rounds of oligomerization and cycloaddition. This novel sequential conjugation technique allowed for the generation of complex peptidomimetic products in which multiple heterogeneous pendant groups were site-specifically positioned along the oligomer scaffold. Studies of a water-soluble estradiol-ferrocene peptoid conjugate demonstrated a potential application for the modular synthesis of biosensors.

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页码：1497 / 1502

页数：6

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