Estrogen receptor ligands. Part 13: Dihydrobenzoxathiin SERAMs with an optimized antagonist side chain

被引：31

作者：

Blizzard, TA ^{[1
]}

DiNinno, F ^{[1
]}

Chen, HY ^{[1
]}

Kim, S ^{[1
]}

Wu, JY ^{[1
]}

Chan, WD ^{[1
]}

Birzin, ET ^{[1
]}

Yang, YT ^{[1
]}

Pal, LY ^{[1
]}

Hayes, EC ^{[1
]}

DaSilva, CA ^{[1
]}

Rohrer, SP ^{[1
]}

Schaeffer, JM ^{[1
]}

Hammond, ML ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

SERMs; SERAMs; estrogen;

D O I：

10.1016/j.bmcl.2005.05.089

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An optimized side chain for dihydrobenzoxathim SERAMs was discovered and attached to four dihydrobenzoxathim platforms. The novel SERAMs show exceptional estrogen antagonist activity in uterine tissue and an MCF-7 breast cancer cell assay. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3912 / 3916

页数：5

共 26 条

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