Glycobiome: Bacteria and mucus at the epithelial interface

被引：172

作者：

Ouwerkerk, Janneke P. ^{[1
]}

de Vos, Willem M. ^{[1
,2
,3
]}

Belzer, Clara ^{[1
]}

机构：

[1] Wageningen UR, Microbiol Lab, NL-6703 HB Wageningen, Netherlands

[2] Univ Helsinki, Fac Med, Dept Bacteriol & Immunol, FI-00014 Helsinki, Finland

[3] Univ Helsinki, Fac Vet Med, Dept Vet Biosci, FI-00014 Helsinki, Finland

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2013年 / 27卷 / 01期

基金：

欧洲研究理事会;

关键词：

Gastrointestinal tract/*microbiology; Mucins/polysaccharides/glycans; Intestinal mucosa; Mucosal immunity; Microbial interactions/symbiosis; Akkermansia muciniphila; Bacteroides thetaiotaomicron; Inflammatory bowel diseases; Irritable bowel syndrome; Humans; INFLAMMATORY-BOWEL-DISEASE; MUCOSA-ASSOCIATED MICROBIOTA; ABO BLOOD-GROUP; INTESTINAL MICROBIOTA; GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; SPATIAL-ORGANIZATION; BACTEROIDES-THETAIOTAOMICRON; GASTROINTESTINAL-TRACT; PLANT POLYSACCHARIDES;

D O I：

10.1016/j.bpg.2013.03.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The human gastrointestinal tract is colonised with a dense and diverse microbial community, that is an important player in human health and physiology. Close to the epithelial cells the mucosal microbiota is separated from the host with a thin lining of host derived glycans, including the cell surface glycocalyx and the extracellular secreted mucus. The mucosa-associated microbial composition differs from the luminal content and could be particularly important for nutrient exchange, communication with the host, development of the immune system, and resistance against invading pathogens. The mucosa-associated microbiota has adapted to the glycan rich environment by the production of mucus-degrading enzymes and mucus-binding extracellular proteins, and include mucus-degrading specialists such as Akkermansia muciniphila and Bacteroides thetaiotaomicron. This review is focussed on the host-microbe interactions within the glycan landscape at the epithelial interface and considers the spatial organisation and composition of the mucosa-associated microbiota in health and disease. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：25 / 38

页数：14

共 122 条

[1] Enterotypes of the human gut microbiome [J].

Arumugam, Manimozhiyan ;

Raes, Jeroen ;

Pelletier, Eric ;

Le Paslier, Denis ;

Yamada, Takuji ;

Mende, Daniel R. ;

Fernandes, Gabriel R. ;

Tap, Julien ;

Bruls, Thomas ;

Batto, Jean-Michel ;

Bertalan, Marcelo ;

Borruel, Natalia ;

Casellas, Francesc ;

Fernandez, Leyden ;

Gautier, Laurent ;

Hansen, Torben ;

Hattori, Masahira ;

Hayashi, Tetsuya ;

Kleerebezem, Michiel ;

Kurokawa, Ken ;

Leclerc, Marion ;

Levenez, Florence ;

Manichanh, Chaysavanh ;

Nielsen, H. Bjorn ;

Nielsen, Trine ;

Pons, Nicolas ;

Poulain, Julie ;

Qin, Junjie ;

Sicheritz-Ponten, Thomas ;

Tims, Sebastian ;

Torrents, David ;

Ugarte, Edgardo ;

Zoetendal, Erwin G. ;

Wang, Jun ;

Guarner, Francisco ;

Pedersen, Oluf ;

de Vos, Willem M. ;

Brunak, Soren ;

Dore, Joel ;

Weissenbach, Jean ;

Ehrlich, S. Dusko ;

Bork, Peer .

NATURE, 2011, 473 (7346) :174-180

[2] Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin [J].

Aspholm-Hurtig, M ;

Dailide, G ;

Lahmann, M ;

Kalia, A ;

Ilver, D ;

Roche, N ;

Vikström, S ;

Sjöström, R ;

Lindén, S ;

Bäckström, A ;

Lundberg, C ;

Arnqvist, A ;

Mahdavi, J ;

Nilsson, UJ ;

Velapatiño, B ;

Gilman, RH ;

Gerhard, M ;

Alarcon, T ;

López-Brea, M ;

Nakazawa, T ;

Fox, JG ;

Correa, P ;

Dominguez-Bello, MG ;

Perez-Perez, GI ;

Blaser, MJ ;

Normark, S ;

Carlstedt, I ;

Oscarson, S ;

Teneberg, S ;

Berg, DE ;

Borén, T .

SCIENCE, 2004, 305 (5683) :519-522

[3] The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo [J].

Atuma, C ;

Strugala, V ;

Allen, A ;

Holm, L .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2001, 280 (05) :G922-G929

[4] Host-bacterial mutualism in the human intestine [J].

Bäckhed, F ;

Ley, RE ;

Sonnenburg, JL ;

Peterson, DA ;

Gordon, JI .

SCIENCE, 2005, 307 (5717) :1915-1920

[5] Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon [J].

Barcelo, A ;

Claustre, J ;

Moro, F ;

Chayvialle, JA ;

Cuber, JC ;

Plaisancié, P .

GUT, 2000, 46 (02) :218-224

[6] THE ROLE OF SPECIFIC IgG AND COMPLEMENT IN COMBATING A PRIMARY MUCOSAL INFECTION OF THE GUT EPITHELIUM [J].

Belzer, C. ;

Liu, Q. ;

Carroll, M. C. ;

Bry, L. .

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY, 2011, 1 (04) :311-318

[7] Microbes inside-from diversity to function: the case of Akkermansia [J].

Belzer, Clara ;

de Vos, Willem M. .

ISME JOURNAL, 2012, 6 (08) :1449-1458

[8] Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, Bacteroides thetaiotaomicron, to the suckling period [J].

Bjursell, Magnus K. ;

Martens, Eric C. ;

Gordon, Jeffrey I. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) :36269-36279

[9]

Bomba A, 1996, BERL MUNCH TIERARZTL, V109, P428

[10] Mucin Muc2 Deficiency and Weaning Influences the Expression of the Innate Defense Genes Reg3β, Reg3γ and Angiogenin-4 [J].

Burger-van Paassen, Nanda ;

Loonen, Linda M. P. ;

Witte-Bouma, Janneke ;

Korteland-van Male, Anita M. ;

de Bruijn, Adrianus C. J. M. ;

van der Sluis, Maria ;

Lu, Peng ;

Van Goudoever, Johannes B. ;

Wells, Jerry M. ;

Dekker, Jan ;

Van Seuningen, Isabelle ;

Renes, Ingrid B. .

PLOS ONE, 2012, 7 (06)

← 1 2 3 4 5 6 7 8 9 10 →