Membrane fusion:: SNAREs and regulation

被引：163

作者：

Malsam, J. ^{[1
]}

Kreye, S. ^{[1
]}

Soellner, T. H. ^{[1
]}

机构：

[1] Heidelberg Univ, Biochem Ctr, D-69120 Heidelberg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2008年 / 65卷 / 18期

基金：

美国国家卫生研究院;

关键词：

exocytosis; fusion; vesicle; tether; synaptotagmin; SM protein; Munc13; complexin;

D O I：

10.1007/s00018-008-8352-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis.

引用

页码：2814 / 2832

页数：19

共 219 条

[161] Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin [J].

Schiavo, G ;

Gu, QM ;

Prestwich, GD ;

Sollner, TH ;

Rothman, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13327-13332

[162] RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone [J].

Schoch, S ;

Castillo, PE ;

Jo, T ;

Mukherjee, K ;

Geppert, M ;

Wang, Y ;

Schmitz, F ;

Malenka, RC ;

Südhof, TC .

NATURE, 2002, 415 (6869) :321-326

[163] More than 1,000 putative new human signalling proteins revealed by EST data mining [J].

Schultz, J ;

Doerks, T ;

Ponting, CP ;

Copley, RR ;

Bork, P .

NATURE GENETICS, 2000, 25 (02) :201-204

[164] Sec1p directly stimulates SNARE-mediated membrane fusion in vitro [J].

Scott, BL ;

Van Komen, JS ;

Irshad, H ;

Liu, S ;

Wilson, KA ;

McNew, JA .

JOURNAL OF CELL BIOLOGY, 2004, 167 (01) :75-85

[165] A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion [J].

Seals, DF ;

Eitzen, G ;

Margolis, N ;

Wickner, WT ;

Price, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) :9402-9407

[166] Synaptotagmin-syntaxin interaction: The C-2 domain as a Ca2+-dependent electrostatic switch [J].

Shao, XG ;

Fernandez, I ;

Zhang, XY ;

Sudhof, TC ;

Rizo, J .

NEURON, 1997, 18 (01) :133-142

[167] Selective activation of cognate SNAREpins by Sec1/Munc18 proteins [J].

Shen, Jingshi ;

Tareste, David C. ;

Paumet, Fabienne ;

Rothman, James E. ;

Melia, Thomas J. .

CELL, 2007, 128 (01) :183-195

[168] Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis [J].

Shibasaki, T ;

Sunaga, Y ;

Fujimoto, K ;

Kashima, Y ;

Seino, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (09) :7956-7961

[169] Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 [J].

Shorter, J ;

Beard, MB ;

Seemann, J ;

Dirac-Svejstrup, AB ;

Warren, G .

JOURNAL OF CELL BIOLOGY, 2002, 157 (01) :45-62

[170] Anatomy and dynamics of a supramolecular membrane protein cluster [J].

Sieber, Jochen J. ;

Willig, Katrin I. ;

Kutzner, Carsten ;

Gerding-Reimers, Claas ;

Harke, Benjamin ;

Donnert, Gerald ;

Rammner, Burkhard ;

Eggeling, Christian ;

Hell, Stefan W. ;

Grubmueller, Helmut ;

Lang, Thorsten .

SCIENCE, 2007, 317 (5841) :1072-1076

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