Genetic support and diversity of acquired extended-spectrum β-lactamases in Gram-negative rods

被引：123

作者：

Poirel, Laurent

Bonnin, Remy A.

Nordmann, Patrice

机构：

[1] Hop Bicetre, AP HP, Serv Bacteriol Virol, INSERM Emerging Resistance Antibiot U914,Fac Med, K Bicetre, France

[2] Univ Paris 11, K Bicetre, France

来源：

INFECTION GENETICS AND EVOLUTION | 2012年 / 12卷 / 05期

关键词：

beta-Lactamases; Integron; Transposon; Insertion sequence; ESBL; CLASS; 3; INTEGRON; ACINETOBACTER-BAUMANNII; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; ANTIBIOTIC-RESISTANCE; CTX-M; KLEBSIELLA-PNEUMONIAE; CLASS-1; MULTIDRUG-RESISTANCE; CLINICAL ISOLATE;

D O I：

10.1016/j.meegid.2012.02.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Genes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are either TEM- or SHV-derivatives, CTX-M-like enzymes and less frequently of the GES, PER, or VEB types. The mechanisms at the origin of their acquisition are diverse, and mostly are related to insertion sequences, transposons and class 1 integrons. This diversity of genetic vehicles at the origin of these mobilization/acquisition processes may explain spread of ESBLs worldwide. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：883 / 893

页数：11

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