Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

被引：23

作者：

Cryle, MJ

Stuthe, JMU

de Montellano, PRO

De Voss, JJ ^{[1
]}

机构：

[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 05期

关键词：

D O I：

10.1039/b315911f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel cyclopropyl containing fatty acids are good substrates for P450(BM3) catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6x10(10) s(-1)) and the absence of any cationic intermediate.

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页码：512 / 513

页数：2

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