Carbon-carbon bond cleavage by cytochrome P450BioI (CYP107H1)

被引：69

作者：

Cryle, MJ ^{[1
]}

De Voss, JJ ^{[1
]}

机构：

[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 01期

关键词：

D O I：

10.1039/b311652b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cytochrome P450(Biol) (CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional P450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.

引用

页码：86 / 87

页数：2

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