Self-Assembly of One- and Two-Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions

被引:67
作者
Kitagishi, Hiroaki [1 ]
Kakikura, Yasuaki [1 ]
Yamaguchi, Hiroyasu [2 ]
Oohora, Koji [1 ]
Harada, Akira [2 ]
Hayashi, Takashi [1 ]
机构
[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Sci, Dept Macromol Sci, Toyonaka, Osaka 5600043, Japan
关键词
cytochrome b(562); heme proteins; protein modifications; self-assembly; supramolecular chemistry; SUPRAMOLECULAR POLYMERS; MYOGLOBIN; CHEMISTRY;
D O I
10.1002/anie.200804006
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Supramolecular protein polymers: When a heme moiety was introduced to the surface of an apo-cytochrome b562(H63C) mutant, supramolecular polymers formed through noncovalent heme-heme pocket interactions. The incorporation of a heme triad as a pivot molecule in the protein polymer further led to a two-dimensional protein network structure, which was visualized by tapping-mode atomic force microscopy (see picture). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:1271 / 1274
页数:4
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