Cyclocondensation reactions of 5-aminopyrazoles, pyruvic acids and aldehydes. Multicomponent approaches to pyrazolopyridines and related products

被引：82

作者：

Chebanov, Valentin A.

Sakhno, Yana I.

Desenko, Sergey M.

Chernenko, Vitaliy N.

Musatov, Vladimir I.

Shishkina, Svetlana V.

Shishkin, Oleg V.

Kappe, C. Oliver

机构：

[1] Natl Acad Sci Ukraine, State Sci Inst Single Crystals, Dept Heterocycl Cpds Chem, UA-61001 Kharkov, Ukraine

[2] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria

[3] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

TETRAHEDRON | 2007年 / 63卷 / 05期

关键词：

heterocycles; cyclocondensation; multicomponent reactions; microwave-assisted organic synthesis; pyruvic acid derivatives; 5-aminopyrazoles;

D O I：

10.1016/j.tet.2006.11.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of 3-substituted 5-aminopyrazoles with arylidenepyruvic acids and their synthetic precursors, pyruvic acid and aromatic aldehydes, were studied. Several different reaction pathways for these cyclocondensation reactions were established depending on the reaction conditions and building block selection. The formation of pyrazolo[3,4-b]pyridine-6-carboxylic acids as major products and related compounds was discussed from the mechanistic point of view. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1229 / 1242

页数：14

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