Electrochemical Methods of Carbamazepine Determination

被引：17

作者：

Garcia-Garcia, M. A. ^{[1
]}

Dominguez-Renedo, O. ^{[1
]}

Alonso-Lomillo, A. ^{[1
]}

Arcos-Martinez, M. J. ^{[1
]}

机构：

[1] Univ Burgos, Dpto Quim, Area Quim Analit, Fac Ciencias, Burgos 09001, Spain

来源：

SENSOR LETTERS | 2009年 / 7卷 / 04期

关键词：

Silver Nanoparticles; Screen-Printed Electrodes; Carbamazepine; Adsorptive Stripping Voltammetry; Enzymatic Biosensor; Horseradish Peroxidase; PERFORMANCE LIQUID-CHROMATOGRAPHY; SCREEN-PRINTED ELECTRODES; STRIPPING VOLTAMMETRY; TRACE-METALS; CARBAMAZEPINE-10,11-EPOXIDE; REGRESSION; MERCURY; SERUM; HPLC; FILM;

D O I：

10.1166/sl.2009.1114

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Glassy carbon (GCE), screen-printed carbon (SPCE) and silver nanoparticle-modified carbon screen-printed (AgNPs/SPCE) electrodes are assessed in the determination of carbamazepine (CBZ) using the oxidation signal obtained from differential-pulse adsorptive stripping voltammetry (DPAdSV). Amperometric analysis of CBZ was also performed using an electrochemical biosensor based on the immobilization of the enzyme horseradish peroxidase (HRP) on a SPCE. The best detection limit (0.938 +/- 0.006 mu M) was obtained by using the AgNPs/SPCE. But the best selectivity was obtained with the HRP based electrode. The AgNPs/SPCE and the HRP-based SPCE developed in this work were successfully applied to CBZ determination in pharmaceutical preparations. Interferences of other antiepileptic pharmaceuticals as Phenitoin and Phenobarbital on CBZ measurement were also studied.

引用

页码：586 / 591

页数：6

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