Mouse phenogenomics: The fast track to "systems metabolism"

被引：37

作者：

Argmann, CA

Chambon, P

Auwerx, J ^{[1
]}

机构：

[1] Univ Strasbourg 1, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch Graffenstaden, France

[2] Inst Clin Souris, F-67404 Illkirch Graffenstaden, France

来源：

CELL METABOLISM | 2005年 / 2卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2005.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

With the completion of the many genomes, genetics is positioned to meet physiology. In this review, we summarize the coming of "systems metabolism" in mammals through the use of the mouse, as a model system to study metabolism. Building on mouse genetics with increasingly sophisticated clinical and molecular phenotyping strategies has enabled scientists to now tackle complex biomedical questions, such as those related to the pathogenesis of the common metabolic disorders. The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse.

引用

页码：349 / 360

页数：12

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